(S)-2-Benzyloxycarbonylamino-4-phenyl-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester

Base Information

Chemical Name:(S)-2-Benzyloxycarbonylamino-4-phenyl-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester
CAS No.:146765-85-7
Molecular Formula:C₂₂H₂₂N₂O₆
Molecular Weight:410.426
Hs Code.:

Synonyms:(S)-2-Benzyloxycarbonylamino-4-phenyl-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-Benzyloxycarbonylamino-4-phenyl-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester

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Technology Process of (S)-2-Benzyloxycarbonylamino-4-phenyl-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester

There total 1 articles about (S)-2-Benzyloxycarbonylamino-4-phenyl-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 83793-44-6,127862-89-9,135911-27-2,138812-70-1
Z-homophenylalanine

: 146765-85-7
(S)-2-Benzyloxycarbonylamino-4-phenyl-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 24 ℃; for 6h;
DOI:10.1002/jps.2600820102

Reference yield: 43.0%

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 146765-85-7
(S)-2-Benzyloxycarbonylamino-4-phenyl-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester

: 146765-87-9
(S)-2-((S)-2-Benzyloxycarbonylamino-4-phenyl-butyrylamino)-3-methyl-butyric acid

Guidance literature:: With triethylamine; In tetrahydrofuran; water; at 24 ℃; for 0.5h;
DOI:10.1002/jps.2600820102

Reference yield:

: 146765-85-7
(S)-2-Benzyloxycarbonylamino-4-phenyl-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester

: (S)-2-Amino-N-[(S)-1-(2-chloro-ethylcarbamoyl)-2-methyl-propyl]-4-phenyl-butyramide; hydrobromide

Guidance literature:: Multi-step reaction with 4 steps

1: 43 percent / triethylamine / tetrahydrofuran; H₂O / 0.5 h / 24 °C

2: 53 percent / dicyclohexylcarbodiimide (DCC) / tetrahydrofuran / 4 h / 24 °C

3: 42 percent / triethylamine / tetrahydrofuran; H₂O / 3 h / 5 °C

4: 58 percent / concd aq. hydrobromic acid / acetic acid / 0.5 h / 24 °C

With hydrogen bromide; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; water; acetic acid;
DOI:10.1002/jps.2600820102