N-[3-(2-acetylamino-thiazol-4-ylmethyl)-5-hydrazinocarbonylmethylsulfanyl-[1,2,4]triazol-4-yl]-4-chloro-benzamide

Base Information

• Chemical Name: N-[3-(2-acetylamino-thiazol-4-ylmethyl)-5-hydrazinocarbonylmethylsulfanyl-[1,2,4]triazol-4-yl]-4-chloro-benzamide
• CAS No.: 933985-30-9
• Molecular Formula: C₁₇H₁₇ClN₈O₃S₂
• Molecular Weight: 480.959

Synonyms:N-[3-(2-acetylamino-thiazol-4-ylmethyl)-5-hydrazinocarbonylmethylsulfanyl-[1,2,4]triazol-4-yl]-4-chloro-benzamide

Chemical Property of N-[3-(2-acetylamino-thiazol-4-ylmethyl)-5-hydrazinocarbonylmethylsulfanyl-[1,2,4]triazol-4-yl]-4-chloro-benzamide

Chemical Property:

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Technology Process of N-[3-(2-acetylamino-thiazol-4-ylmethyl)-5-hydrazinocarbonylmethylsulfanyl-[1,2,4]triazol-4-yl]-4-chloro-benzamide

There total 4 articles about N-[3-(2-acetylamino-thiazol-4-ylmethyl)-5-hydrazinocarbonylmethylsulfanyl-[1,2,4]triazol-4-yl]-4-chloro-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

[5-(2-acetylamino-thiazol-4-ylmethyl)-4-(4-chloro-benzoylamino)-4H-[1,2,4]triazol-3-ylsulfanyl]-acetic acid methyl ester (933985-18-3) → N-[3-(2-acetylamino-thiazol-4-ylmethyl)-5-hydrazinocarbonylmethylsulfanyl-[1,2,4]triazol-4-yl]-4-chloro-benzamide (933985-30-9)

Guidance literature:

With aluminum oxide; hydrazine hydrate; microwave irradiation;

DOI:10.1016/j.bmc.2007.01.043

Reference yield:

N-[4-(4-amino-5-mercapto-4H-[1,2,4]triazol-3-ylmethyl)-thiazol-2-yl]-acetamide → N-[3-(2-acetylamino-thiazol-4-ylmethyl)-5-hydrazinocarbonylmethylsulfanyl-[1,2,4]triazol-4-yl]-4-chloro-benzamide (933985-30-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 77 percent / NaOH / 0 °C

2: 78 percent / sodium hydroxide; acidic alumina / microwave irradiation

3: 82 percent / hydrazine hydrate; acidic alumina / microwave irradiation

With aluminum oxide; sodium hydroxide; hydrazine hydrate;

DOI:10.1016/j.bmc.2007.01.043

Reference yield:

4-chloro-benzoyl chloride (122-01-0) → N-[3-(2-acetylamino-thiazol-4-ylmethyl)-5-hydrazinocarbonylmethylsulfanyl-[1,2,4]triazol-4-yl]-4-chloro-benzamide (933985-30-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 77 percent / NaOH / 0 °C

2: 78 percent / sodium hydroxide; acidic alumina / microwave irradiation

3: 82 percent / hydrazine hydrate; acidic alumina / microwave irradiation

With aluminum oxide; sodium hydroxide; hydrazine hydrate;

DOI:10.1016/j.bmc.2007.01.043

upstream raw materials:

[5-(2-acetylamino-thiazol-4-ylmethyl)-4-(4-chloro-benzoylamino)-4H-[1,2,4]triazol-3-ylsulfanyl]-acetic acid methyl ester

N-[3-(2-acetylamino-thiazol-4-ylmethyl)-5-mercapto-[1,2,4]triazol-4-yl]-4-chloro-benzamide

4-chloro-benzoyl chloride

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