Trofosfamide

Base Information

• Chemical Name: Trofosfamide
• CAS No.: 22089-22-1
• Molecular Formula: C9H18 Cl3 N2 O2 P
• Molecular Weight: 323.587
• Hs Code.: 2934999090
• European Community (EC) Number: 244-770-8
• NSC Number: 314928,314927,109723
• UNII: H64JRU6GJ0
• DSSTox Substance ID: DTXSID60865031
• Nikkaji Number: J5.178K
• Wikipedia: Trofosfamide
• Wikidata: Q10384947
• NCI Thesaurus Code: C1268
• Metabolomics Workbench ID: 153797
• ChEMBL ID: CHEMBL462019
• Mol file: 22089-22-1.mol

Synonyms:Genoxal Trofosfamida;Ixoten;N,N,N'-tris(2-chloroethyl)-N'-O-propylene phosphoric acid ester diamide;trofosfamide;trophosphamide;Z 4828

Chemical Property of Trofosfamide

Chemical Property:

• Vapor Pressure: 2.09E-06mmHg at 25°C
• Melting Point: 47-49°C
• Boiling Point: 393.7°Cat760mmHg
• Flash Point: 191.9°C
• PSA: 42.59000
• Density: 1.35g/cm³
• LogP: 2.77310
• Storage Temp.: -20?C Freezer
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 322.017148
• Heavy Atom Count: 17
• Complexity: 265

Purity/Quality:

99% ^*data from raw suppliers

Trofosfamide >98.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(P(=O)(OC1)N(CCCl)CCCl)CCCl
• Recent ClinicalTrials: Trofosfamide Versus Adriamycin in Elderly Patients With Soft Tissue Sarcoma (STS)
• Recent EU Clinical Trials: Quality of life in patients with non-adipocyte soft tissue sarcoma under
• Therapeutic Function: Cancer chemotherapy

Technology Process of Trofosfamide

There total 1 articles about Trofosfamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ trofosfamide (22089-22-1)

Guidance literature:

Aus d. entspr. Phosphorsaeuredichlorid u.d.entspr. Hydroxypropylamin o. Ethylen- iminopropenol;

Reference yield:

trofosfamide (22089-22-1) → 4-Hydroperoxytrofosfamid (39800-25-4)

Guidance literature:

With ozone;

DOI:10.1002/bms.1200040404

Downstream raw materials:

4-Hydroperoxytrofosfamid