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22089-22-1

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Basic Information
CAS No.: 22089-22-1
Name: trofosfamide
Molecular Structure:
Molecular Structure of 22089-22-1 (trofosfamide)
Formula: C9H18 Cl3 N2 O2 P
Molecular Weight: 323.587
Synonyms: 2H-1,3,2-Oxazaphosphorine,2-[bis(2-chloroethyl)amino]-3-(2-chloroethyl)tetrahydro-, 2-oxide (8CI);3-(2-Chloroethyl)-2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine2-oxide; Asta Z 4828; Ixoten; NSC 109723; Trifosfamide; Trilofosfamida;Trilophosphamide; Triphosphamide; Trisfosfamide; Trofosfamid; Trofosfamide; Trophosphamid;Trophosphamide; Z 4828
Density: 1.35g/cm3
Melting Point: 47-49°C
Boiling Point: 393.7°Cat760mmHg
Flash Point: 191.9°C
Safety: Poison by intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by ingestion. Human mutation data reported. Human systemic effects by unspecified routes: hematuria, leukopenia, and thrombocytopenia. When heated to decomposition it emits very toxic fumes of Cl−, NOx, and POx.
PSA: 42.59000
LogP: 2.77310
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Chemistry

IUPAC Name: N,N,2-tris(2-chloroethyl)-1-oxo-6-oxa-2-aza-1λ5-phosphacyclohexan-1-amine 
Molecular Formula: C9H18Cl3N2O2P
Molecular Weight: 323.61g/mol 
EINECS: 244-770-8
Density: 1.35g/cm3
Boiling Point: 393.7°C at 760mmHg
Flash Point: 191.9°C 
Freely Rotating Bonds: 7
Polar Surface Area: 42.59 Å2
Index of Refraction: 1.518
Molar Refractivity: 72.42 cm3
Molar Volume: 238.7 cm3
Polarizability: 28.7 ×10-24 cm3
Surface Tension: 46.1 dyne/cm
Enthalpy of Vaporization: 64.36 kJ/mol
Vapour Pressure: 2.09E-06 mmHg at 25°C 
The Cas Register Number of Trophosphamide is 22089-22-1.The chemical synonyms of Trophosphamide (CAS NO.22089-22-1) are (R)-N,N,3-Tris(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide ; 2-[Bis(2-chloroethyl)amino]-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxaphosphorine 2-oxide ; 2H-1,3,2-oxazaphosphorin-2-amine, N,N,3-tris(2-chloroethyl)tetrahydro-, 2-oxide ; 2H-1,3,2-Oxazaphosphorin-2-amine, N,N,3-tris(2-chloroethyl)tetrahydro-, 2-oxide (9CI)  ; 2H-1,3,2-Oxazaphosphorin-2-amine, N,N,3-tris(2-chloroethyl)tetrahydro-, 2-oxide, (R)- ; N,N,3-Tris(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide ; N,N,3-Tris(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine-2-Oxide ; Trilophosphamide ; 2-(Bis(2-chloroethyl)amino)-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide ; 2H-1,3, 2-Oxazaphosphorine, 2-[bis (2-chloroethyl)amino]-3-(2-chloroethyl)tetrahydro-, 2-oxide ; 2H-1,3,2-Oxaphosphorin-2-amine, tetrahydro-N,N, 3-tris(2-chloroethyl)-, 2-oxide ; 2H-1,3,2-Oxazaphosphorin-2-amine, N,N,3-tris (2-chloroethyl)tetrahydro-, 2-oxide ; 2H-1,3,2-Oxazaphosphorin-2-amine, N,N,3-tris(2-chloroethyl)tetrahydro-, 2-oxide, (S)- ; 2H-1,3,2-Oxazaphosphorine, 2-(bis(2-chloroethyl)amino)-3-(2-chloroethyl)tetrahydro-, 2-oxide ; 3-(2-Chloroethyl)-2-(bis(2-chloroethyl)amino)perhydro-2H-1,3,2-oxazaphosphorine 2-oxide ; Cyclophosphamide, N-monochloroethyl derivative ; Ifosfamide mustard ; Ixoten ; N,N,3-Tris(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide ; N,N,N'-Tris(2-chloroethyl)-N',O-propylene phosphoric acid ester diamide ; N,N-3'-tris(2-chloroethyl)tetrahydro-2H-1,3,2 oxazaphosphorin-2-amine, 2-oxide ; Trifosfamide .The molecular structure of Trophosphamide (CAS NO.22089-22-1) is.

Uses

 Trophosphamide (CAS NO.22089-22-1) is used as anti carcinoma drug.

Toxicity Data With Reference

1.    

mma-esc 10 mmol/L

     ARTODN    Archives of Toxicology. 33 (1975),225.
2.    

sln-dmg-unr 1 mmol/L/24H

     MUREAV    Mutation Research. 33 (1975),221.
3.    

cyt-hmn:leu 100 mg/L

     HUMAA7    Humangenetik. 5 (1968),321.
4.    

cyt-rat-ipr 25 mg/kg

     HUMAA7    Humangenetik. 5 (1968),321.
5.    

mnt-mus-ipr 80 mg/kg/24H

     MUREAV    Mutation Research. 56 (1978),319.
6.    

cyt-ham-ipr 3300 µg/kg

     ARTODN    Archives of Toxicology. 38 (1977),35.
7.    

unr-hmn TDLo:50 mg/kg:BLD,KID

     SAMJAF    South African Medical Journal. 53 (1978),886.
8.    

orl-rat LD50:202 mg/kg

     MDACAP    Medicamentos de Actualidad. 13 (1977),115.
9.    

scu-rat LD50:210 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 23 (1973),922.
10.    

ivn-rat LD50:90 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 23 (1973),922.
11.    

orl-mus LD50:464 mg/kg

     MDACAP

Consensus Reports

EPA Genetic Toxicology Program.

Safety Profile

Poison by intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by ingestion. Human mutation data reported. Human systemic effects by unspecified routes: hematuria, leukopenia, and thrombocytopenia. When heated to decomposition it emits very toxic fumes of Cl−, NOx, and POx.