4-({7-[2-fluoro-4-(methylsulfonyl)phenyl]-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-N-hydroxy-1-piperidinecarboximidamide

Base Information

Chemical Name:4-({7-[2-fluoro-4-(methylsulfonyl)phenyl]-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-N-hydroxy-1-piperidinecarboximidamide
CAS No.:1001399-04-7
Molecular Formula:C₁₉H₂₃FN₆O₄S
Molecular Weight:450.494
Hs Code.:

Synonyms:4-({7-[2-fluoro-4-(methylsulfonyl)phenyl]-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-N-hydroxy-1-piperidinecarboximidamide

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Chemical Property of 4-({7-[2-fluoro-4-(methylsulfonyl)phenyl]-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-N-hydroxy-1-piperidinecarboximidamide

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Technology Process of 4-({7-[2-fluoro-4-(methylsulfonyl)phenyl]-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-N-hydroxy-1-piperidinecarboximidamide

There total 1 articles about 4-({7-[2-fluoro-4-(methylsulfonyl)phenyl]-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-N-hydroxy-1-piperidinecarboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1001399-05-8
4-({7-[2-fluoro-4-(methylsulfonyl)phenyl]-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-1-piperidinecarbonitrile

: 1001399-04-7
4-({7-[2-fluoro-4-(methylsulfonyl)phenyl]-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-N-hydroxy-1-piperidinecarboximidamide

Guidance literature:: With hydroxylamine hydrochloride; sodium carbonate; In ethanol; for 2h; Heating / reflux;

Reference yield: 9.0%

: 1001399-04-7
4-({7-[2-fluoro-4-(methylsulfonyl)phenyl]-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-N-hydroxy-1-piperidinecarboximidamide

: 79-31-2
isobutyric Acid

: 1001399-06-9
7-[2-fluoro-4-(methylsulfonyl)phenyl]-4-({1-[5-(1-methylethyl)-1,2,4-oxadiazol-3-yl]-4-piperidinyl}oxy)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: isobutyric Acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

4-({7-[2-fluoro-4-(methylsulfonyl)phenyl]-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-N-hydroxy-1-piperidinecarboximidamide; In N,N-dimethyl-formamide; at 20 - 100 ℃; for 1.5h;