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High purity Isobutyric acid 99% TOP1 supplier in China
Cas No: 79-31-2
No Data 100 Gram 2000 Metric Ton/Day Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High quality 79-31-2 Isobutyric acid
Cas No: 79-31-2
USD $ 1300.0-1600.0 / Kilogram 1 Kilogram 99999 Kilogram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
Isobutyric acid, 2-Methylpropionic acid, Isobutanoic acid
Cas No: 79-31-2
No Data 1 Metric Ton Metric Ton/Day Nanjing Yuance Industry&Trade Co., Ltd. Contact Supplier
Isobutyric acid
Cas No: 79-31-2
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Isobutyric acid
Cas No: 79-31-2
No Data 1 Kilogram 20 Metric Ton/Month Henan Allgreen Chemical Co.,Ltd Contact Supplier
Factory Supply Isobutyric acid
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Isobutyric acid
Cas No: 79-31-2
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Isobutyric acid 90%,99%,99.5%
Cas No: 79-31-2
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Isobutyric acid CAS:79-31-2
Cas No: 79-31-2
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TIANFU-CHEM Isobutyric acid
Cas No: 79-31-2
No Data 1 Metric Ton 10 Metric Ton/Day Henan Tianfu Chemical Co., Ltd. Contact Supplier

79-31-2 Usage

Definition

ChEBI: A branched fatty acid comprising propanoic acid carrying a methyl branch at C-2.

Hazards & Safety Information

Production method :Isobutyric acid can be derived from the oxidation of isobutanol. Category : Flammable liquids Toxicity classification : high toxicity Acute Toxicity : Oral-Rat LD50: 280 mg/kg Flammability hazard characteristics :Combust when meeting fire, high temperature and strong oxidant; Release irritating smoke when combusting. Storage and transport characteristics? :Complete packaging; light loading and unloading; warehouse ventilation; away from the fire and high temperature; stored separately with oxidants and alkali. Fire extinguishing agent : foam, dry powder, carbon dioxide, sand

Reactivity Profile

Isobutyric acid corrodes aluminum and other metals. Flammable hydrogen gas may accumulate in enclosed spaces in which this reaction has taken place [USCG, 1999].

Content analysis

Determined by the same content analysis method of "butyric acid (03454)".

Preparation

By oxidation of isobutyl alcohol.

Uses

1. Isobutyric acid is mainly used in the synthesis of isobutyric acid esters, such as methyl isobutyrate, propyl ester, isoamyl ester and benzyl ester. It can also be used as edible flavor and used in pharmaceutical. 2. GB 2760-1996 provides for isobutyric acid as the food flavors allowed to use. It is mainly used for the preparation of butter, apple, caramel, cheese, bread, yeast and other flavors. 3. Isobutyric acid is not more important than butyric acid, but has the similar uses with n-butyric acid. Isobutyric acid is mainly used to produce the corresponding esters, such as methyl isobutyrate with apricot incense, propyl isobutyrate with pineapple flavor, isobutyl isobutyrate with banana flavor, octyl isobutyrate with grapes taste, benzyl isobutyrate with jasmine smell, etc. It can be used for preparing flavors and solvents and also used in the manufacture of varnishes and plasticizers. Isobutyric acid has some important derivatives that, in the industry, is actually used for the production of isobutyronitrile intermediates, and then converted to isobutylamidine hydrochloride that is the raw materials of pesticide diazinon. 4. Used for the raw materials of perfume and perfume ester, and also used as the solvents of textile auxiliaries (in the form of salt) and a variety of chemical reactions.

Production method

The preparation of isobutyric acid is similar with butyric acid, which is performed by the direct oxidation of isobutyl alcohol and isobutyraldehyde. Isobutyric acid can be directly generated from the oxidation of isobutyraldehyde in air or oxygen. Other manufacturing methods have isobutyronitrile hydrolysis and methacrylic acid hydrogenation. The oxidation of 2-methyl-1-nitropropane to prepare isobutyric acid can also obtain a higher yield. The purification of Isobutyric acid can be realized by azeotropic distillation with water, and anhydrous isobutyric acid can be obtained by the extractive distillation from carbon tetrachloride. Propylene and formic acid ester can react at 50 °C with the catalysis of hydrofluoric acid to generate methyl isobutyrate and propyl isobutyrate. Application: Isobutyric acid is not more important than butyric acid, but has the similar uses with n-butyric acid. Isobutyric acid is mainly used to produce the corresponding esters, such as methyl isobutyrate with apricot incense, propyl isobutyrate with pineapple flavor, isobutyl isobutyrate with banana flavor, octyl isobutyrate with grapes taste, benzyl isobutyrate with jasmine smell, etc. It can be used for preparing flavors and solvents and also used in the manufacture of varnishes and plasticizers. Isobutyric acid has some important derivatives that, in the industry, is actually used for the production of isobutyronitrile intermediates, and then converted to isobutylamidine hydrochloride that is the raw materials of pesticide diazinon.

Chemical Properties

Isobutyric acid has strong penetrating odor of rancid butter. The odor and flavor are similar to n-butyric acid.

Fire Hazard

Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Chemical properties

Colorless oily liquid; strong irritating odor; miscible with water; soluble in alcohol, ether and so on.

Uses

Isobutyric Acid is a flavoring agent that is a colorless liquid with a strong, penetrating odor, resembling butter. it is miscible in alcohol, propylene glycol, glycerin, mineral oil, and most fixed oils and sol- uble in water. it is obtained by chemical synthesis. it is also termed isopropylformic acid.

Uses

Manufacture of esters for solvents, flavors and perfume bases, disinfecting agent, varnish, deliming hides, tanning agent.

Description

Isobutyric acid has an odor and flavor similar to n-butyric acid. Prepared via oxidation of isobutyl alcohol.

Health Hazard

Inhalation causes irritation of nose and throat. Ingestion causes irritation of mouth and stomach. Contact with eyes or skin causes irritation.

Air & Water Reactions

Flammable. Water soluble

Use limits

FEMA (mg/kg): soft drinks 4.1; cold drinks 12; candy 41; baked food 38; gummy candy 470; margarine 30. Moderate use as limits (FDA § 172.515, 2000).

Occurrence

Reported found in several essential oils: Arnica montana, Roman chamomile, Laurus nobilis, imperatoria, and in carob fruits (Siliqua dulcis); also identified in the essence of Seseli tortuosum, Artemisia transiliensis. Reported found in apple, banana, lingonberry, cranberry, currants, guava, papaya, grapes, pineapple, raspberry, strawberry, celery, potato, bell pepper, tomato, peppermint oil, breads, cheeses, butter, fish, cooked beef and pork, hop oil, beer, rum, cognac, whiskies, cider, honey, grape wines, cocoa, coffee, tea, peanuts, passion fruit, plums, mushrooms, mango, rice, shoyu, sake, buckwheat, laurel, dried bonito, Bourbon vanilla, shrimps, scallops and Chinese quince

Aroma threshold values

Detection: 10 ppb to 9.5 ppm; aroma characteristics at 10 ppm: acidic pungent, dairy buttery and cheesy with fruity undertones.

Taste threshold values

Taste characteristics at 15 ppm: acidic, sour dairy, creamy, cheese, cultured dairy nuance.

Hazard

Toxic by ingestion, strong irritant to tissue.

Toxicity

GRAS (FEMA). LD50 280 mg/kg (rat, oral).

Chemical Properties

clear colorless liquid

Standard for Maximum Allowable Amount

English name of the additive: isobutyric acid English name of the food allowed to use the additive : food Additive Function:Spice used in food Maximum allowable use (g/kg) Maximum allowable residue (g/kg) The spice ingredients for preparing essence shall not exceed the maximum allowable use and maximum allowable residue in GB 2760.

General Description

A colorless liquid with a light odor of rancid butter. Flash point 132°F. Density 7.9 lb / gal. Corrosive to metals and tissue.

Purification Methods

Distil the acid from KMnO4, then redistil it from P2O5. [Beilstein 2 H 288, 2 I 126, 2 II 257, 2 III 637, 2 IV 843.]
InChI:InChI=1/2C4H8O2/c2*1-3(2)4(5)6/h2*3H,1-2H3,(H,5,6)

79-31-2 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Alfa Aesar (L04038)  Isobutyric acid, 99%    79-31-2 100ml 180.0CNY Detail
Alfa Aesar (L04038)  Isobutyric acid, 99%    79-31-2 500ml 240.0CNY Detail
Alfa Aesar (L04038)  Isobutyric acid, 99%    79-31-2 2500ml 962.0CNY Detail
Sigma-Aldrich (58360)  Isobutyricacid  puriss. p.a., ≥99.5% 79-31-2 58360-100ML 355.68CNY Detail
Supelco (46935-U)  Isobutyricacid  analytical standard 79-31-2 46935-U 205.92CNY Detail

79-31-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name isobutyric acid

1.2 Other means of identification

Product number -
Other names Isobutyric acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:79-31-2 SDS

79-31-2Synthetic route

2-methyl-propan-1-ol
78-83-1

2-methyl-propan-1-ol

isobutyric Acid
79-31-2

isobutyric Acid

Conditions
ConditionsYield
With 2,2,6,6-tetramethyl-piperidine-N-oxyl; trichloroisocyanuric acid; sodium hydrogencarbonate; sodium bromide In water; acetone at 20℃; for 3h;100%
With tert.-butylhydroperoxide; copper(ll) bromide In water; dimethyl sulfoxide at 20℃; for 1.2h; Inert atmosphere;88%
With aluminium trichloride; silver bromate In acetonitrile for 0.65h; Heating;83%
(4S)-4-benzyl-3-(2-methylpropionyl)-2-oxazolidinone
869563-40-6

(4S)-4-benzyl-3-(2-methylpropionyl)-2-oxazolidinone

isobutyric Acid
79-31-2

isobutyric Acid

Conditions
ConditionsYield
With lithium hydroxide; dihydrogen peroxide; sodium sulfite In tetrahydrofuran; water at 0℃; for 2h;100%
isobutyraldehyde
78-84-2

isobutyraldehyde

isobutyric Acid
79-31-2

isobutyric Acid

Conditions
ConditionsYield
With N-hydroxyphthalimide; oxygen In acetonitrile at 30℃; for 3h; Schlenk technique;99%
With dihydrogen peroxide In water; acetonitrile at 45℃; for 1h; chemoselective reaction;98%
With oxygen In n-heptane at 20℃; under 750.06 Torr; Rate constant; Mechanism; Kinetics; effect of various solvents, further pressure and temperature;96.2%
methyl-d3 2-methylpropanoate
54526-87-3

methyl-d3 2-methylpropanoate

A

1,1,1-trideuteromethanol
1849-29-2

1,1,1-trideuteromethanol

B

isobutyric Acid
79-31-2

isobutyric Acid

Conditions
ConditionsYield
With water; ion exchange resin Product distribution / selectivity;A 99%
B n/a
1,1,1-trifluoro-5-methyl-2,4-hexanedione
30984-28-2

1,1,1-trifluoro-5-methyl-2,4-hexanedione

isobutyric Acid
79-31-2

isobutyric Acid

Conditions
ConditionsYield
With oxygen; sodium hydrogencarbonate In acetonitrile for 4h; Molecular sieve; Irradiation;99%
N,N'-diisobutyryltetrahydropyrazole
23832-41-9

N,N'-diisobutyryltetrahydropyrazole

A

pyrazolidine dihydrogen chloride

pyrazolidine dihydrogen chloride

B

isobutyric Acid
79-31-2

isobutyric Acid

Conditions
ConditionsYield
With hydrogenchloride for 8h; Heating;A 98.8%
B n/a
poly(methacrylic acid)
79-41-4

poly(methacrylic acid)

isobutyric Acid
79-31-2

isobutyric Acid

Conditions
ConditionsYield
With phenylsilane; C12H23N2O2P In tetrahydrofuran at 23℃; for 2h;98%
With sodium tetrahydroborate; sodium hydroxide In water at 20 - 60℃;90%
With potassium hydroxide; hydrogen; K3HCo(CN)5; β‐cyclodextrin for 24h; Ambient temperature;89%
3-bromo-3-methyl-but-1-ene
865-58-7

3-bromo-3-methyl-but-1-ene

isobutyric Acid
79-31-2

isobutyric Acid

Conditions
ConditionsYield
Stage #1: 3-bromo-3-methyl-but-1-ene With triacetylglycerol for 0.833333h;
Stage #2: With vanadium dioxide at 10℃; for 1.33333h; Temperature;
96%
2,2-dimethylmalonic acid
595-46-0

2,2-dimethylmalonic acid

isobutyric Acid
79-31-2

isobutyric Acid

Conditions
ConditionsYield
With poly-4-vinylpyridine In N,N-dimethyl-formamide for 0.05h; microwave irradiation;91%
In water for 0.25h; Decarboxylation; microwave irradiation;83%
at 190℃;
In neat (no solvent) at 192℃; Kinetics; Thermodynamic data; ΔH(excit.), ΔS(excit.), ΔF(excit.);
Isobutyronitrile
78-82-0

Isobutyronitrile

isobutyric Acid
79-31-2

isobutyric Acid

Conditions
ConditionsYield
With benzene-1,2-dicarboxylic acid for 0.666667h; microwave irradiation;90%
With potassium phosphate buffer; nitrilase from Alcaligenes faecalis ATCC8750 at 30℃; for 58h; pH=7.3;71%
With hydrogenchloride; water at 170℃; Kinetics; Thermodynamic data; Further Variations:; Temperatures; hydrothermolysis;
isobutyraldehyde
78-84-2

isobutyraldehyde

A

isobutyric Acid
79-31-2

isobutyric Acid

B

peroxides

peroxides

Conditions
ConditionsYield
With oxygen; cobalt naphthenate00 at 50 - 55℃; for 2h; Product distribution; other time, temperature and catalyst;;A 90%
B n/a
methacrylic acid methyl ester
80-62-6

methacrylic acid methyl ester

isobutyric Acid
79-31-2

isobutyric Acid

Conditions
ConditionsYield
With potassium hydroxide; hydrogen; K3HCo(CN)5; β‐cyclodextrin for 24h; Ambient temperature;87%
isobutyl isobutanoate
97-85-8

isobutyl isobutanoate

isobutyric Acid
79-31-2

isobutyric Acid

Conditions
ConditionsYield
With hydrogenchloride In acetone for 4h; Reagent/catalyst; Solvent; Reflux;87%
N,N'-diisobutyrylhexahydropyridazine
68387-96-2

N,N'-diisobutyrylhexahydropyridazine

A

1,2,3,4,5,6-hexahydropyridazine hydrochloride
89990-53-4

1,2,3,4,5,6-hexahydropyridazine hydrochloride

B

isobutyric Acid
79-31-2

isobutyric Acid

Conditions
ConditionsYield
With hydrogenchloride for 8h; Heating;A 86.3%
B n/a
4-bromo-2-methyl-octene-3

4-bromo-2-methyl-octene-3

A

isobutyric Acid
79-31-2

isobutyric Acid

B

valeric acid
109-52-4

valeric acid

Conditions
ConditionsYield
With ruthenium(IV) oxide; sodium periodate In dichloromethane; water; acetonitrile for 6h; Ambient temperature;A n/a
B 85%
With ruthenium(IV) oxide; sodium periodate In dichloromethane; water; acetonitrile for 6h; Ambient temperature;
3-methyl-butan-2-one
563-80-4

3-methyl-butan-2-one

A

formic acid
64-18-6

formic acid

B

isobutyric Acid
79-31-2

isobutyric Acid

Conditions
ConditionsYield
With perchloric acid; bromamine T In water at 35 - 40℃; Kinetics; Mechanism; Thermodynamic data; ΔH and ΔS; var. solv.: D2O;A 82%
B 82%
With perchloric acid; mercury(II) diacetate; N-bromoacetamide In water at 30℃; Kinetics; Mechanism; effect of the concentrations of NBA, MIK, acid and Hg(OAc)2; effect of the ionic strength; D2O isotopic effect; further temperatures;
indole
120-72-9

indole

2-Methylpropionic anhydride
97-72-3

2-Methylpropionic anhydride

A

1-(1H-indol-3-yl)-2-methylpropan-1-one
57642-07-6

1-(1H-indol-3-yl)-2-methylpropan-1-one

B

isobutyric Acid
79-31-2

isobutyric Acid

Conditions
ConditionsYield
With Cl(1-)*C5H14NO(1+)*3ZnCl2 at 120℃; for 0.166667h; Friedel-Crafts Acylation; Microwave irradiation; Green chemistry; regioselective reaction;A 81%
B n/a
methanol
67-56-1

methanol

1-naphthylmethyl 2-methylpropanoate
72524-21-1

1-naphthylmethyl 2-methylpropanoate

A

monoisopropylmethylnaphthalene
16727-91-6

monoisopropylmethylnaphthalene

B

1-(methoxymethyl)naphthalene
5903-23-1

1-(methoxymethyl)naphthalene

C

isobutyric Acid
79-31-2

isobutyric Acid

Conditions
ConditionsYield
at 20℃; Rate constant; Quantum yield; Irradiation;A 6%
B 80%
C n/a
methacrylonitrile
126-98-7

methacrylonitrile

isobutyric Acid
79-31-2

isobutyric Acid

Conditions
ConditionsYield
With potassium hydroxide; hydrogen; K3HCo(CN)5; β‐cyclodextrin at 70℃; for 24h;80%
Methacrylamide
79-39-0

Methacrylamide

isobutyric Acid
79-31-2

isobutyric Acid

Conditions
ConditionsYield
With potassium hydroxide; hydrogen; K3HCo(CN)5; β‐cyclodextrin at 70℃; for 24h;77%
isobutyraldehyde oxime
151-00-8

isobutyraldehyde oxime

A

isobutyraldehyde
78-84-2

isobutyraldehyde

B

isobutyric Acid
79-31-2

isobutyric Acid

Conditions
ConditionsYield
With hydrogenchloride; sodium chlorite; water at 20℃; for 0.0833333h;A 76%
B 8%
1-butoxy-1-isobutoxy butane
20266-12-0

1-butoxy-1-isobutoxy butane

A

2-methyl-propan-1-ol
78-83-1

2-methyl-propan-1-ol

B

butyl butyrate
109-21-7

butyl butyrate

C

isobutyl n-butyrate
539-90-2

isobutyl n-butyrate

D

isobutyric Acid
79-31-2

isobutyric Acid

E

butyric acid
107-92-6

butyric acid

F

butan-1-ol
71-36-3

butan-1-ol

Conditions
ConditionsYield
With oxygen; cobalt(II) acetate at 90℃; under 750.06 Torr; Mechanism; Rate constant; other oxygen pressure;A 5.5%
B 3%
C 3.5%
D 5%
E 73.5%
F 7%
Methyl isobutyrate
547-63-7

Methyl isobutyrate

isobutyric Acid
79-31-2

isobutyric Acid

Conditions
ConditionsYield
With toluene-4-sulfonic acid In water; acetone at 100℃; under 11103.3 Torr; for 4h;72%
With Methyltrichlorosilane; sodium iodide In acetonitrile for 12h; Product distribution; Heating; var. carboxylic acid alkyl esters; var. times; other temp.: room tem temp.;70%
In sodium hydroxide at 25℃; Thermodynamic data;
2-Methylpropionic anhydride
97-72-3

2-Methylpropionic anhydride

phenylacetylene
536-74-3

phenylacetylene

phenylacetyl chloride
103-80-0

phenylacetyl chloride

A

3-phenylnaphthalen-1-ol
30069-65-9

3-phenylnaphthalen-1-ol

B

isobutyric Acid
79-31-2

isobutyric Acid

Conditions
ConditionsYield
Stage #1: 2-Methylpropionic anhydride; phenylacetylene; phenylacetyl chloride at 190℃; for 48h; Inert atmosphere;
Stage #2: With potassium hydroxide In water at 100℃; for 13 - 15h;
A 70%
B n/a
L-valine
72-18-4

L-valine

isobutyric Acid
79-31-2

isobutyric Acid

Conditions
ConditionsYield
With ruthenium trichloride; sodium periodate In tetrachloromethane; water; acetonitrile for 60h;66%
2-methyl-propan-1-ol
78-83-1

2-methyl-propan-1-ol

A

isobutyl isobutanoate
97-85-8

isobutyl isobutanoate

B

isobutyric Acid
79-31-2

isobutyric Acid

Conditions
ConditionsYield
With sodium bromate; sodium hydrogensulfite for 2h; Ambient temperature;A 65%
B 7%
3-hydroxy-2-methyl-1-propene
513-42-8

3-hydroxy-2-methyl-1-propene

A

1,1,3-trimethyl glutaric acid
19265-05-5

1,1,3-trimethyl glutaric acid

B

isobutyric Acid
79-31-2

isobutyric Acid

Conditions
ConditionsYield
With potassium hydroxide In cyclohexene at 300℃; for 20h;A 16.6%
B 58.5%
With potassium hydroxide at 300℃;
3,3-dimethyl-2-phenylsulphonyl-2-trimethylsilyloxirane
129613-02-1

3,3-dimethyl-2-phenylsulphonyl-2-trimethylsilyloxirane

A

2-methyl-2-(trimethylsilyl)propanoic acid
139117-09-2

2-methyl-2-(trimethylsilyl)propanoic acid

B

2-bromo-2-methylpropanoyltrimethylsilane
128588-99-8

2-bromo-2-methylpropanoyltrimethylsilane

C

isobutyric Acid
79-31-2

isobutyric Acid

Conditions
ConditionsYield
With magnesium bromide ethyl etherate In diethyl ether at 0℃; for 2.33333h;A 24%
B 57%
C 9%
ethyl 2-methyl-2-methyl tellurium propionate
474094-06-9

ethyl 2-methyl-2-methyl tellurium propionate

A

dimethyl ditelluride
20334-43-4

dimethyl ditelluride

B

isobutyric Acid
79-31-2

isobutyric Acid

C

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

Conditions
ConditionsYield
With potassium hydroxide In tetrahydrofuran; water at 70℃; for 3h; Inert atmosphere;A 52%
B 14%
C 22%
isobutyric Acid
79-31-2

isobutyric Acid

recorcinol
108-46-3

recorcinol

1-(2,4-dihydroxyphenyl)-2-methyl-1-propanone
29048-54-2

1-(2,4-dihydroxyphenyl)-2-methyl-1-propanone

Conditions
ConditionsYield
With boron trifluoride diethyl etherate at 90℃; for 1.5h; Inert atmosphere;100%
With zinc(II) chloride at 125 - 140℃;
With boron trifluoride
3-(2-vinyloxyethoxy)-1,2-propylene carbonate
54107-24-3

3-(2-vinyloxyethoxy)-1,2-propylene carbonate

isobutyric Acid
79-31-2

isobutyric Acid

Isobutyric acid 1-[2-(2-oxo-[1,3]dioxolan-4-ylmethoxy)-ethoxy]-ethyl ester
127827-85-4

Isobutyric acid 1-[2-(2-oxo-[1,3]dioxolan-4-ylmethoxy)-ethoxy]-ethyl ester

Conditions
ConditionsYield
With heptafluorobutyric Acid at 75℃; for 3h;100%
isobutyric Acid
79-31-2

isobutyric Acid

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

1-(1H-imidazol-1-yl)-2-methylpropan-1-one
4122-53-6

1-(1H-imidazol-1-yl)-2-methylpropan-1-one

Conditions
ConditionsYield
In tetrahydrofuran100%
In tetrahydrofuran Heating;
In N,N-dimethyl-formamide for 3h; Ambient temperature;
phenethylamine
64-04-0

phenethylamine

isobutyric Acid
79-31-2

isobutyric Acid

2-methyl-N-(2′-phenethyl)-propionamide
71022-62-3

2-methyl-N-(2′-phenethyl)-propionamide

Conditions
ConditionsYield
With dmap In chloroform at 25℃; for 1h;100%
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; (EtO)2PO-N(Ph)-SO2CF3 In dichloromethane for 0.5h; Acylation;97%
With thio-xanthene-9-one; 2-(diisopropylamino)-3-(2-methylbenzo[b]thiophen-3-yl)cycloprop-2-en-1-one In dichloromethane at 20℃; for 9h; Inert atmosphere; Irradiation;84%
isobutyric Acid
79-31-2

isobutyric Acid

2,3-diamino-nitrobenzene
3694-52-8

2,3-diamino-nitrobenzene

2-Isopropyl-4-nitro-1H-benzimidazole
208773-27-7

2-Isopropyl-4-nitro-1H-benzimidazole

Conditions
ConditionsYield
With hydrogenchloride Heating;100%
allyl 1-{[(α-chloroethoxy)carbonyl]aminomethyl}-1-cyclohexane acetate
649748-00-5

allyl 1-{[(α-chloroethoxy)carbonyl]aminomethyl}-1-cyclohexane acetate

isobutyric Acid
79-31-2

isobutyric Acid

1-{[(α-isobutanoyloxyethoxy)carbonyl]aminomethyl}-1-cyclohexane acetic acid allyl ester

1-{[(α-isobutanoyloxyethoxy)carbonyl]aminomethyl}-1-cyclohexane acetic acid allyl ester

Conditions
ConditionsYield
With 4-methyl-morpholine at 0 - 20℃; for 16.5h;100%
With 4-methyl-morpholine at 0 - 20℃; for 16.5h;100%
With 4-methyl-morpholine at 0 - 20℃; for 16.5h;100%
With 4-methyl-morpholine at 0 - 20℃; for 16.5h;100%
With tributyl-amine In toluene at 20℃; Product distribution / selectivity;
(SbCl3O)2H(O2CCF3)

(SbCl3O)2H(O2CCF3)

isobutyric Acid
79-31-2

isobutyric Acid

(SbCl3O)2H(O2CCH(CH3)2)

(SbCl3O)2H(O2CCH(CH3)2)

Conditions
ConditionsYield
In dichloromethane reflux for 24 h; filtered, washed with CH2Cl2, dried in vac.; elem. anal.;100%
isobutyric Acid
79-31-2

isobutyric Acid

benzyl azide
622-79-7

benzyl azide

N-benzylisobutyramide
4774-58-7

N-benzylisobutyramide

Conditions
ConditionsYield
With 2,2'-dipyridyldiselenide; trimethylphosphane In toluene at 0 - 20℃; Staudinger-Vilarrasa reaction; Inert atmosphere;100%
O-(1-chloroethyl) S-ethyl carbonothioate
101506-43-8

O-(1-chloroethyl) S-ethyl carbonothioate

isobutyric Acid
79-31-2

isobutyric Acid

1-{[(ethylthio)carbonyl]oxy}ethyl 2-methylpropionate

1-{[(ethylthio)carbonyl]oxy}ethyl 2-methylpropionate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine at 55℃; for 48h;100%
(2-chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methanamine
1332076-30-8

(2-chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methanamine

isobutyric Acid
79-31-2

isobutyric Acid

N-((2-chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)isobutyramide
1332076-36-4

N-((2-chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)isobutyramide

Conditions
ConditionsYield
Stage #1: isobutyric Acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide for 0.25h; Inert atmosphere;
Stage #2: (2-chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methanamine In N,N-dimethyl-formamide Inert atmosphere;
100%
4-(2-chloro-6-(piperidin-4-ylmethyl)pyrido[3,2-d]pyrimidin-4-yl)morpholine
1332076-38-6

4-(2-chloro-6-(piperidin-4-ylmethyl)pyrido[3,2-d]pyrimidin-4-yl)morpholine

isobutyric Acid
79-31-2

isobutyric Acid

1-(4-((2-chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)piperidin-1-yl)-2-methylpropan-1-one
1332076-41-1

1-(4-((2-chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)piperidin-1-yl)-2-methylpropan-1-one

Conditions
ConditionsYield
Stage #1: isobutyric Acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 0.25h; Inert atmosphere;
Stage #2: 4-(2-chloro-6-(piperidin-4-ylmethyl)pyrido[3,2-d]pyrimidin-4-yl)morpholine In N,N-dimethyl-formamide Inert atmosphere;
100%
1-Boc-2-benzylpiperazine

1-Boc-2-benzylpiperazine

isobutyric Acid
79-31-2

isobutyric Acid

C20H30N2O3

C20H30N2O3

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 2h;100%
(-)-methyl 6-((benzyloxy)methyl)-2-azabicyclo[2.1.1]hexane-5-carboxylate trifluoroacetate

(-)-methyl 6-((benzyloxy)methyl)-2-azabicyclo[2.1.1]hexane-5-carboxylate trifluoroacetate

isobutyric Acid
79-31-2

isobutyric Acid

(1R,4S,5S,6R)-methyl 6-((benzyloxy)methyl)-2-iso-butyryl-2-azabicyclo[2.1.1]hexane-5-carboxylate

(1R,4S,5S,6R)-methyl 6-((benzyloxy)methyl)-2-iso-butyryl-2-azabicyclo[2.1.1]hexane-5-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 1h; Inert atmosphere; Sealed tube;100%
2-methyl-propan-1-ol
78-83-1

2-methyl-propan-1-ol

isobutyric Acid
79-31-2

isobutyric Acid

isobutyl isobutanoate
97-85-8

isobutyl isobutanoate

Conditions
ConditionsYield
With 1-butyl-3-methylimidazolium hydrogen sulfate at 80℃; under 760.051 Torr; for 3h; Reagent/catalyst; Temperature;99.8%
With sulfuric acid
With titanium(IV) oxide at 235℃;
isobutyric Acid
79-31-2

isobutyric Acid

isobutyryl chloride
79-30-1

isobutyryl chloride

Conditions
ConditionsYield
With phosphorus trichloride at 45 - 55℃; for 6h;99.6%
With trichloroacetonitrile; triphenylphosphine In dichloromethane at 30℃; Temperature; Inert atmosphere;99.76%
Stage #1: isobutyric Acid With phosphorus trichloride at 60℃; for 2h;
Stage #2: With hydrogenchloride for 0.3h; Temperature;
97.5%
isobutyric Acid
79-31-2

isobutyric Acid

isobutyraldehyde
78-84-2

isobutyraldehyde

Conditions
ConditionsYield
With thexylbromoborane dimethyl sulfide complex In carbon disulfide; dichloromethane at -20 - 20℃; for 1h;99%
With 9-borabicyclo[3.3.1]nonane dimer; lithium dihydrido borata-bicyclo[3.3.0]nonane In tetrahydrofuran for 1h; Ambient temperature;94%
With iron(II) oxide at 430 - 490℃;
isobutyric Acid
79-31-2

isobutyric Acid

2,4-dimethylpentan-3-one
565-80-0

2,4-dimethylpentan-3-one

Conditions
ConditionsYield
manganese(II)carbonate In MARLOTHERM S (dibenzyltoluene) at 360 - 380℃; Product distribution / selectivity;99%
With thorium dioxide at 490℃;
With calcium chloride at 580 - 600℃;
tetra(n-butyl)ammonium hydroxide
2052-49-5

tetra(n-butyl)ammonium hydroxide

isobutyric Acid
79-31-2

isobutyric Acid

tetrabutylammonium 2-methylpropionate
60154-69-0

tetrabutylammonium 2-methylpropionate

Conditions
ConditionsYield
In methanol at 20℃; for 6h;99%
In water at 60℃; for 2h;98%
In water at 20℃; for 0.5h; Product distribution / selectivity;
In methanol at 20℃; for 0.5h; Product distribution / selectivity;
norbornene
498-66-8

norbornene

isobutyric Acid
79-31-2

isobutyric Acid

exo-isobutyric acid bicyclo[2.2.1]hept-2-yl ester

exo-isobutyric acid bicyclo[2.2.1]hept-2-yl ester

Conditions
ConditionsYield
iron(III) trifluoromethanesulfonate In dibutyl ether at 80℃; for 18h;99%
2-(4,4-ethylenedioxycyclohex-1-ylidene)propanol
19620-34-9

2-(4,4-ethylenedioxycyclohex-1-ylidene)propanol

isobutyric Acid
79-31-2

isobutyric Acid

2-(4,4-ethylenedioxycyclohexylidene)propyl 2-methylpropanoate
1085762-37-3

2-(4,4-ethylenedioxycyclohexylidene)propyl 2-methylpropanoate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 5h;99%
norborn-2-ene
498-66-8

norborn-2-ene

isobutyric Acid
79-31-2

isobutyric Acid

norbornenyl-2-methyl propionate

norbornenyl-2-methyl propionate

Conditions
ConditionsYield
iron(III) trifluoromethanesulfonate In dibutyl ether at 80℃; for 18h;99%
isobutyric Acid
79-31-2

isobutyric Acid

anethole
104-46-1

anethole

isobutyric acid 2-(4-methoxyphenyl)-1-methylethyl ester

isobutyric acid 2-(4-methoxyphenyl)-1-methylethyl ester

Conditions
ConditionsYield
Stage #1: isobutyric Acid With 2,6-dimethylpyridine; 10-methyl-9-(2,4,6-trimethylphenyl) acridinium tetrafluoroborate; thiophenol In 1,2-dichloro-ethane at 0 - 23℃; for 0.25h; Inert atmosphere;
Stage #2: anethole In 1,2-dichloro-ethane for 62h; Inert atmosphere; Irradiation; regioselective reaction;
99%
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide
1365037-86-0

5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide

isobutyric Acid
79-31-2

isobutyric Acid

5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-[1-(3-methylbutanoyl)piperidin-4-yl]-1H-pyrazole-3-carboxamide

5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-[1-(3-methylbutanoyl)piperidin-4-yl]-1H-pyrazole-3-carboxamide

Conditions
ConditionsYield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In tetrahydrofuran for 16h;99%
isobutyric Acid
79-31-2

isobutyric Acid

(R)-tert-butyl 3-methylpiperazine-1-carboxylate
163765-44-4

(R)-tert-butyl 3-methylpiperazine-1-carboxylate

(R)-3-methyl-4-(isobutyryl)piperazine-1-carboxylic acid tert-butyl ester

(R)-3-methyl-4-(isobutyryl)piperazine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 10h; Inert atmosphere;99%
With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 10h;99%
phorbol-20-trityl ether
82400-03-1

phorbol-20-trityl ether

isobutyric Acid
79-31-2

isobutyric Acid

phorbol 12,13-diisobutyrate-20-trityl

phorbol 12,13-diisobutyrate-20-trityl

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 18h;99%
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