C₂₁H₃₄O₄Si

Base Information

• Chemical Name: C₂₁H₃₄O₄Si
• CAS No.: 1280213-93-5
• Molecular Formula: C₂₁H₃₄O₄Si
• Molecular Weight: 378.584
• Mol file: 1280213-93-5.mol

Synonyms:C₂₁H₃₄O₄Si

Chemical Property of C₂₁H₃₄O₄Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₃₄O₄Si

There total 7 articles about C₂₁H₃₄O₄Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

C15H20O4 (1280213-80-0) + t-butyldimethylsiyl triflate (69739-34-0) → C21H34O4Si (1280213-93-5)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at -78 ℃; for 0.0333333h;

DOI:10.1016/j.tetlet.2011.01.078

Reference yield:

Acrylic acid (R)-1-benzyloxymethyl-but-3-enyl ester (640298-47-1) → C21H34O4Si (1280213-93-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 6 h / Reflux

2.1: dihydrogen peroxide; sodium hydroxide / methanol; water / 0.02 h / 0 °C

3.1: diisobutylaluminium hydride / toluene / 1 h / -78 °C

3.2: 1 h / -40 °C

4.1: potassium hydroxide / tetrahydrofuran; water / 11 h / 20 °C

5.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 0.25 h / 0 °C

5.2: 2 h / 0 °C

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.03 h / -78 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; dihydrogen peroxide; chloroformic acid ethyl ester; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; toluene; 3.2: Horner-Wadsworth-Emmons olefination / 4.1: intramolecular oxy-Michael reaction;

DOI:10.1016/j.tetlet.2011.01.078

Reference yield:

(1S,4R,6S)-4-Benzyloxymethyl-3,7-dioxa-bicyclo[4.1.0]heptan-2-one (130194-53-5) → C21H34O4Si (1280213-93-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / toluene / 1 h / -78 °C

1.2: 1 h / -40 °C

2.1: potassium hydroxide / tetrahydrofuran; water / 11 h / 20 °C

3.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 0.25 h / 0 °C

3.2: 2 h / 0 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.03 h / -78 °C

With chloroformic acid ethyl ester; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; potassium hydroxide; In tetrahydrofuran; dichloromethane; water; toluene; 1.2: Horner-Wadsworth-Emmons olefination / 2.1: intramolecular oxy-Michael reaction;

DOI:10.1016/j.tetlet.2011.01.078

upstream raw materials:

Acrylic acid (R)-1-benzyloxymethyl-but-3-enyl ester

C₁₇H₂₂O₅

C₁₅H₁₈O₅

C₁₅H₂₀O₄

Downstream raw materials:

C₃₆H₅₆O₄Si₂