(E)-1-methyl-4-(3,3,3-trifluoro-1-iodoprop-1-en-1-yl)benzene

Base Information

• Chemical Name: (E)-1-methyl-4-(3,3,3-trifluoro-1-iodoprop-1-en-1-yl)benzene
• CAS No.: 219517-83-6
• Molecular Formula: C₁₀H₈F₃I
• Molecular Weight: 312.073
• Mol file: 219517-83-6.mol

Synonyms:(E)-1-methyl-4-(3,3,3-trifluoro-1-iodoprop-1-en-1-yl)benzene

Chemical Property of (E)-1-methyl-4-(3,3,3-trifluoro-1-iodoprop-1-en-1-yl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-1-methyl-4-(3,3,3-trifluoro-1-iodoprop-1-en-1-yl)benzene

There total 5 articles about (E)-1-methyl-4-(3,3,3-trifluoro-1-iodoprop-1-en-1-yl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2,2-difluoro-2-(fluorosulfonyl)acetate (680-15-9) + (E)-1-(1,2-diiodovinyl)-4-methylbenzene (219517-81-4) → (E)-1-methyl-4-(3,3,3-trifluoro-1-iodoprop-1-en-1-yl)benzene (219517-83-6)

Guidance literature:

With copper(l) iodide; In N,N-dimethyl-formamide; at 75 - 80 ℃;

DOI:10.1021/jo9816663

Reference yield: 86.0%

1-(p-methylphenyl)-3,3,3-trifluoropropyne (82203-82-5) → (E)-1-methyl-4-(3,3,3-trifluoro-1-iodoprop-1-en-1-yl)benzene (219517-83-6)

Guidance literature:

With lithium iodide; In acetic acid; at 75 ℃; for 16h;

DOI:10.1016/j.jfluchem.2008.01.002

Reference yield:

Langlois reagent (2926-29-6) + 4-n-methylphenylacetylene (766-97-2) → (Z)-1-methyl-4-(3,3,3-trifluoro-1-iodoprop-1-en-1-yl)benzene + (E)-1-methyl-4-(3,3,3-trifluoro-1-iodoprop-1-en-1-yl)benzene (219517-83-6)

Guidance literature:

With iodine pentoxide; sodium hydrogencarbonate; In water; 1,2-dichloro-ethane; at 110 ℃; for 22h; Overall yield = 72%; Sealed tube;

DOI:10.1021/ol501380e

upstream raw materials:

2,2-difluoro-2-(fluorosulfonyl)acetate

(E)-1-(1,2-diiodovinyl)-4-methylbenzene

4-n-methylphenylacetylene

1-(p-methylphenyl)-3,3,3-trifluoropropyne

Downstream raw materials:

(E)-N,N-diethyl-6,6,6-trifluoro-4-p-tolylhex-4-en-2-yl-1-amine

(E)-6,6,6-trifluoro-4-p-tolylhex-4-en-2-yl-1-ol

(E)-5,5,5-trifluoro-1-phenyl-3-p-tolylpent-3-en-1-yl