2-amino-5-[2-(dimethylamino)ethyl]-4-(4-nitrophenyl)-3-thiophenecarbonitrile

Base Information

Chemical Name:2-amino-5-[2-(dimethylamino)ethyl]-4-(4-nitrophenyl)-3-thiophenecarbonitrile
CAS No.:607713-63-3
Molecular Formula:C₁₅H₁₆N₄O₂S
Molecular Weight:316.384
Hs Code.:

Synonyms:2-amino-5-[2-(dimethylamino)ethyl]-4-(4-nitrophenyl)-3-thiophenecarbonitrile

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Chemical Property of 2-amino-5-[2-(dimethylamino)ethyl]-4-(4-nitrophenyl)-3-thiophenecarbonitrile

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Technology Process of 2-amino-5-[2-(dimethylamino)ethyl]-4-(4-nitrophenyl)-3-thiophenecarbonitrile

There total 7 articles about 2-amino-5-[2-(dimethylamino)ethyl]-4-(4-nitrophenyl)-3-thiophenecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[4-dimethylamino-1-(4-nitro-phenyl)-butylidene]-malononitrile

: 607713-63-3
2-amino-5-[2-(dimethylamino)ethyl]-4-(4-nitrophenyl)-3-thiophenecarbonitrile

Guidance literature:: With sulfur; diethylamine; In ethanol; at 70 ℃; for 1.5h;
DOI:10.1021/jm050458h

Reference yield:

: 607713-81-5
4-hydroxy-1-(4-nitrophenyl)butan-1-one

: 607713-63-3
2-amino-5-[2-(dimethylamino)ethyl]-4-(4-nitrophenyl)-3-thiophenecarbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / Et₃N / CH₂Cl₂ / 3 h / 0 °C

2: 51 percent / Et₃N / tetrahydrofuran; dimethylformamide / 1.5 h / 85 - 90 °C

3: NH₄OAc; AcOH / benzene / 18 h / Heating

4: Et₂NH; sulfur / ethanol / 1.5 h / 70 °C

With ammonium acetate; sulfur; acetic acid; diethylamine; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; benzene; 3: Knoevenagel condensation / 4: Gewald reaction;
DOI:10.1021/jm050458h

Reference yield:

: 607713-62-2
4-(dimethylamino)-1-(4-nitrophenyl)-1-butanone

: 607713-63-3
2-amino-5-[2-(dimethylamino)ethyl]-4-(4-nitrophenyl)-3-thiophenecarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: NH₄OAc; AcOH / benzene / 18 h / Heating

2: Et₂NH; sulfur / ethanol / 1.5 h / 70 °C

With ammonium acetate; sulfur; acetic acid; diethylamine; In ethanol; benzene; 1: Knoevenagel condensation / 2: Gewald reaction;
DOI:10.1021/jm050458h