Trifluoro-methanesulfonic acid (S)-5-benzyloxymethyl-2-oxo-2,5-dihydro-furan-3-yl ester

Base Information

• Chemical Name: Trifluoro-methanesulfonic acid (S)-5-benzyloxymethyl-2-oxo-2,5-dihydro-furan-3-yl ester
• CAS No.: 133048-95-0
• Molecular Formula: C₁₃H₁₁F₃O₆S
• Molecular Weight: 352.288

Synonyms:Trifluoro-methanesulfonic acid (S)-5-benzyloxymethyl-2-oxo-2,5-dihydro-furan-3-yl ester

Chemical Property of Trifluoro-methanesulfonic acid (S)-5-benzyloxymethyl-2-oxo-2,5-dihydro-furan-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Trifluoro-methanesulfonic acid (S)-5-benzyloxymethyl-2-oxo-2,5-dihydro-furan-3-yl ester

There total 9 articles about Trifluoro-methanesulfonic acid (S)-5-benzyloxymethyl-2-oxo-2,5-dihydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

trifluoromethylsulfonic anhydride (358-23-6) + (3R,4S,5R)-5-Benzyloxymethyl-4-fluoro-3-hydroxy-dihydro-furan-2-one (133048-85-8) → Trifluoro-methanesulfonic acid (S)-5-benzyloxymethyl-2-oxo-2,5-dihydro-furan-3-yl ester (133048-95-0)

Guidance literature:

With pyridine; In dichloromethane;

DOI:10.1016/S0957-4166(00)82381-2

Reference yield:

benzyl bromide (100-39-0) → Trifluoro-methanesulfonic acid (S)-5-benzyloxymethyl-2-oxo-2,5-dihydro-furan-3-yl ester (133048-95-0)

Guidance literature:

Multi-step reaction with 4 steps

1: NaH / tetrahydrofuran

2: aq. trifluoroacetic acid

3: Br₂, Ba(OCOPh)2 / dioxane; H₂O

4: 88 percent / pyridine / CH₂Cl₂

With pyridine; bromine; sodium hydride; barium benzoate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

DOI:10.1016/S0957-4166(00)82381-2

Reference yield:

((3aS,5R,6R,6aR)-6-Fluoro-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-methanol (89747-13-7) → Trifluoro-methanesulfonic acid (S)-5-benzyloxymethyl-2-oxo-2,5-dihydro-furan-3-yl ester (133048-95-0)

Guidance literature:

Multi-step reaction with 4 steps

1: NaH / tetrahydrofuran

2: aq. trifluoroacetic acid

3: Br₂, Ba(OCOPh)2 / dioxane; H₂O

4: 88 percent / pyridine / CH₂Cl₂

With pyridine; bromine; sodium hydride; barium benzoate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

DOI:10.1016/S0957-4166(00)82381-2

upstream raw materials:

trifluoromethylsulfonic anhydride

(3R,4S,5R)-5-Benzyloxymethyl-4-fluoro-3-hydroxy-dihydro-furan-2-one

benzyl bromide

((3aS,5R,6R,6aR)-6-Fluoro-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-methanol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 133048-95-0 Trifluoro-methanesulfonic acid (S)-5-benzyloxymethyl-2-oxo-2,5-dihydro-furan-3-yl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send