N-(methylsulfonyloxy)tetrahydrofuran-2-carbimidoyl chloride

Base Information

• Chemical Name: N-(methylsulfonyloxy)tetrahydrofuran-2-carbimidoyl chloride
• CAS No.: 945989-05-9
• Molecular Formula: C₆H₁₀ClNO₄S
• Molecular Weight: 227.669
• Mol file: 945989-05-9.mol

Synonyms:N-(methylsulfonyloxy)tetrahydrofuran-2-carbimidoyl chloride

Chemical Property of N-(methylsulfonyloxy)tetrahydrofuran-2-carbimidoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-(methylsulfonyloxy)tetrahydrofuran-2-carbimidoyl chloride

There total 1 articles about N-(methylsulfonyloxy)tetrahydrofuran-2-carbimidoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tetrahydrofuran-2-carbaldehyde (7681-84-7) → N-(methylsulfonyloxy)tetrahydrofuran-2-carbimidoyl chloride (945989-05-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium carbonate / methanol; water / 0 - 20 °C

2: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

3: triethylamine / diethyl ether / 0.18 h / 20 °C

With N-chloro-succinimide; sodium carbonate; triethylamine; In methanol; diethyl ether; water; N,N-dimethyl-formamide;

Reference yield: 100.0%

N-(methylsulfonyloxy)tetrahydrofuran-2-carbimidoyl chloride (945989-05-9) + ethyl 3-(2-amino-5-bromopyridin-4-yloxy)-4-chlorobenzoate (945988-77-2) → ethyl 3-(5-bromo-2-(3-(tetrahydrofuran-2-yl)-1,2,4-thiadiazol-5-ylamino)pyridin-4-yloxy)-4-chlorobenzoate

Guidance literature:

N-(methylsulfonyloxy)tetrahydrofuran-2-carbimidoyl chloride; sodium thiocyanide; With pyridine; In acetonitrile; at 40 ℃; for 0.666667h;

ethyl 3-(2-amino-5-bromopyridin-4-yloxy)-4-chlorobenzoate; In acetonitrile; at 60 ℃;

Reference yield: 76.5%

N-(methylsulfonyloxy)tetrahydrofuran-2-carbimidoyl chloride (945989-05-9) + 5-bromo-3-phenoxypyridin-2-amine (953045-12-0) + sodium thiocyanide (540-72-7) → N-(5-bromo-3-phenoxypyridin-2-yl)-3-(tetrahydrofuran-2-yl)-1,2,4-thiadiazol-5-amine (953041-96-8)

Guidance literature:

N-(methylsulfonyloxy)tetrahydrofuran-2-carbimidoyl chloride; sodium thiocyanide; With pyridine; In acetonitrile; at 40 ℃; for 0.666667h;

5-bromo-3-phenoxypyridin-2-amine; In acetonitrile; at 50 ℃;

upstream raw materials:

tetrahydrofuran-2-carbaldehyde

Downstream raw materials:

N-(5-bromo-3-phenoxypyridin-2-yl)-3-(tetrahydrofuran-2-yl)-1,2,4-thiadiazol-5-amine