ethyl 3-(2-amino-5-bromopyridin-4-yloxy)-4-chlorobenzoate

Base Information

• Chemical Name: ethyl 3-(2-amino-5-bromopyridin-4-yloxy)-4-chlorobenzoate
• CAS No.: 945988-77-2
• Molecular Formula: C₁₄H₁₂BrClN₂O₃
• Molecular Weight: 371.618
• Mol file: 945988-77-2.mol

Synonyms:ethyl 3-(2-amino-5-bromopyridin-4-yloxy)-4-chlorobenzoate

Chemical Property of ethyl 3-(2-amino-5-bromopyridin-4-yloxy)-4-chlorobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-(2-amino-5-bromopyridin-4-yloxy)-4-chlorobenzoate

There total 2 articles about ethyl 3-(2-amino-5-bromopyridin-4-yloxy)-4-chlorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.9%

ethyl 3-(2-aminopyridin-4-yloxy)-4-chlorobenzoate (945988-76-1) → ethyl 3-(2-amino-5-bromopyridin-4-yloxy)-4-chlorobenzoate (945988-77-2)

Guidance literature:

With bromine; acetic acid; at 20 ℃; for 0.5h;

Reference yield:

ethyl 4-chloro-3-(2-chloropyridin-4-yloxy)benzoate (945988-69-2) → ethyl 3-(2-amino-5-bromopyridin-4-yloxy)-4-chlorobenzoate (945988-77-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium phosphate; tert-butyl carbazate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / water; toluene / 90 °C

2: bromine; acetic acid / 0.5 h / 20 °C

With potassium phosphate; tert-butyl carbazate; bromine; acetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In water; toluene;

Reference yield: 100.0%

N-(methylsulfonyloxy)tetrahydrofuran-2-carbimidoyl chloride (945989-05-9) + ethyl 3-(2-amino-5-bromopyridin-4-yloxy)-4-chlorobenzoate (945988-77-2) → ethyl 3-(5-bromo-2-(3-(tetrahydrofuran-2-yl)-1,2,4-thiadiazol-5-ylamino)pyridin-4-yloxy)-4-chlorobenzoate

Guidance literature:

N-(methylsulfonyloxy)tetrahydrofuran-2-carbimidoyl chloride; sodium thiocyanide; With pyridine; In acetonitrile; at 40 ℃; for 0.666667h;

ethyl 3-(2-amino-5-bromopyridin-4-yloxy)-4-chlorobenzoate; In acetonitrile; at 60 ℃;

upstream raw materials:

ethyl 3-(2-aminopyridin-4-yloxy)-4-chlorobenzoate

ethyl 4-chloro-3-(2-chloropyridin-4-yloxy)benzoate

Downstream raw materials:

ethyl 3-(2-(3-benzoylthioureido)-5-bromopyridin-4-yloxy)-4-chlorobenzoate

ethyl 3-(5-bromo-2-thioureidopyridin-4-yloxy)-4-chlorobenzoate