1-{4-[5-(4-tert-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-phenyl}isoquinoline

Base Information

Chemical Name:1-{4-[5-(4-tert-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-phenyl}isoquinoline
CAS No.:1395928-50-3
Molecular Formula:C₂₇H₂₃N₃O
Molecular Weight:405.499
Hs Code.:

Synonyms:1-{4-[5-(4-tert-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-phenyl}isoquinoline

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Chemical Property of 1-{4-[5-(4-tert-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-phenyl}isoquinoline

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Technology Process of 1-{4-[5-(4-tert-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-phenyl}isoquinoline

There total 5 articles about 1-{4-[5-(4-tert-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-phenyl}isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 546631-87-2
C₁₈H₁₉BN₂O₃

: 19493-44-8
1-chloroisoquinoline

: 1395928-50-3
1-{4-[5-(4-tert-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-phenyl}isoquinoline

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In toluene; at 110 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.ica.2012.05.010

Reference yield:

: 1710-98-1
p-tert-butyl benzoyl chloride

: 1395928-50-3
1-{4-[5-(4-tert-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-phenyl}isoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine

2.1: trichlorophosphate

3.1: n-butyllithium / hexane / 2 h / -5 °C / Inert atmosphere

3.2: 2.75 h / -50 - 20 °C / Inert atmosphere

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene / 24 h / 110 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium carbonate; triethylamine; trichlorophosphate; In hexane; toluene; 4.1: Suzuki coupling;
DOI:10.1016/j.ica.2012.05.010

Reference yield:

: 5933-32-4
4-bromobenzoic acid hydrazide

: 1395928-50-3
1-{4-[5-(4-tert-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-phenyl}isoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine

2.1: trichlorophosphate

3.1: n-butyllithium / hexane / 2 h / -5 °C / Inert atmosphere

3.2: 2.75 h / -50 - 20 °C / Inert atmosphere

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene / 24 h / 110 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium carbonate; triethylamine; trichlorophosphate; In hexane; toluene; 4.1: Suzuki coupling;
DOI:10.1016/j.ica.2012.05.010