5933-32-4

Basic information

• Product Name: 4-BROMOBENZHYDRAZIDE
• Synonyms: 4-BROMOBENZOYLHYDRAZINE;4-BROMO-BENZOIC ACID HYDRAZIDE;4-BROMOBENZOIC HYDRAZIDE;4-BROMOBENZHYDRAZIDE;4-BROMOBENZOHYDRAZIDE;Benzoic acid, 4-bromo-, hydrazide;Benzoic acid, p-bromo-, hydrazide;p-bromo-benzoicacihydrazide
• CAS NO: 5933-32-4
• Molecular Formula: C₇H₇BrN₂O
• Molecular Weight: 215.05
• EINECS: 227-681-9
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid;Bromine Compounds;Carbonyl Compounds;Hydrazides;Organic Building Blocks
• Mol File: 5933-32-4.mol
• Article Data: 119

Chemical Properties

• Melting Point: 167-169°C
• Boiling Point: 353.2 °C at 760 mmHg
• Flash Point: 167.4 °C
• Appearance: Light beige/Powder
• Density: 1.615 g/cm³
• Vapor Pressure: 1.34E-05mmHg at 25°C
• Refractive Index: 1.615
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 12.09±0.10(Predicted)
• Water Solubility: Soluble in hot methanol (almost transparency). Slightly soluble in water.
• BRN: 777006
• CAS DataBase Reference: 4-BROMOBENZHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMOBENZHYDRAZIDE(5933-32-4)
• EPA Substance Registry System: 4-BROMOBENZHYDRAZIDE(5933-32-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37/39
• WGK Germany: 3
• RTECS: DG4449250
• Hazardous Substances Data: 5933-32-4(Hazardous Substances Data)

Usage

Chemical Properties

Light beige powder

Uses

4-Bromobenzoic hydrazide has been used in the preparation of {2-[1-oxo-3-(4-bromophenyl)-2-propenyl]hydrazide}-4-bromobenzoic acid, {2,2?-[1,4-phenylenebis(1-oxo-2-propene-3,1-diyl)]dihydrazide}-p-bromobenzoic acid and substituted period[1,2-a]pyrimidine-2,4(3H)-diones (PPMDO).

InChI:InChI=1/C7H7BrN2O/c8-6-3-1-5(2-4-6)7(11)10-9/h1-4H,9H2,(H,10,11)

Upstream product

• 5798-75-4 Ethyl 4-bromobenzoate 
• 1633-33-6 4-bromobenzoic anhydride 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 99-90-1 para-bromoacetophenone 
• 82892-00-0 N-(4-bromobenzoyl)imidazole 
• 7803-57-8 hydrazine hydrate 
• 586-75-4 4-chlorobenzoyl chloride 
• 586-76-5 4-Bromobenzoic acid 
• 5798-76-5 phenyl 4-bromobenzoate 

Downstream Products

• 93444-96-3 furfural-(4-bromo-benzoylhydrazone) 
• 74038-71-4 N’-acetyl-4-bromobenzohydrazide 
• 120124-60-9 4-bromo-benzoic acid-(4-nitro-benzylidenehydrazide) 
• 82973-11-3 benzaldehyde-4-bromobenzoylhydrazone 
• 41420-90-0 2-(4-bromophenyl)-1,3,4-oxadiazole 
• 103038-37-5 N-(1-methylethylidene)-4-bromobenzohydrazide 
• 5148-72-1 galactose-(4-bromo-benzoylhydrazone) 
• 5148-75-4 arabinose-(4-bromo-benzoylhydrazone) 

Relevant articles and documents

Pleuromutilin derivative with 1, 3, 4-oxadiazole side chain and preparation and application thereof

The invention belongs to the field of medicinal chemistry, and particularly relates to a pleuromutilin derivative with a 1, 3, 4-oxadiazole side chain and preparation and application thereof The pleuromutilin derivative with the 1, 3, 4-oxadiazole side chain is a compound shown in a formula 2 or a pharmaceutically acceptable salt thereof, and a solvent compound, an enantiomer, a diastereoisomer and a tautomer of the compound shown in the formula 2 or the pharmaceutically acceptable salt thereof or a mixture of the solvent compound, the enantiomer, the diastereoisomer and the tautomer in any proportion, including a racemic mixture. The pleuromutilin derivative has good antibacterial activity, is especially suitable for being used as a novel antibacterial agent for systemic system infection of animals or human beings, and has good water solubility.

Synthesis, fungicidal activity, and 3D-QSAR of tetrazole derivatives containing phenyloxadiazole moieties

In an effort to discover new agents with good fungicidal activities against CDM (cucumber downy mildew), a series of tetrazole derivatives containing phenyloxadiazole moieties were designed and synthesized. The EC50 values for fungicidal activities against CDM were determined. Bioassay results indicated that most synthesized compounds exhibited potential in vivo fungicidal activity against CDM. A CoMFA (comparative molecular field analysis) model based on the bioactivity was developed to identify some primary structural quality for the efficiency. The values of q2 and r2 for the established model were 0.791 and 0.982 respectively, which reliability and predict abilities were verified. Three analogues (q3, q4, q5) were designed and synthesized based on the model. All these compounds exhibited significant fungicidal activity on CDM with the EC50 of 1.43, 1.52, 1.77 mg·L?1. This work could provide a useful instruction for the further structure optimization.

Using m icrowave and ultrasound to synthesis of substituted bis-acyl hydrazone derivatives

In this paper, some new bis-acyl hydrazone derivatives (4a-f) were prepared through the reaction of carboxylic acid hydrazides with 1,4-diacetylbenzene using classical methods, microwave and ultrasound irradiation methods. These compounds are obtained through a series of reactions where some carboxylic acids react with ethanol first in the presence of concentrated sulfuric acid to give the corresponding esters (2a-f), which when treatment with aqueous hydrazine give carboxylic acid hydrazides (3a-f).thus, The results proved that the use of microwave and ultrasound techniques is much better than the classical methods, as it gave a higher yield, shorter reaction time, and the absence of the use of solvents. All newly synthesized compounds were confirmed by IR, (1H & 13C) NMR spectral analysis and the corresponding reactions were monitored by TLC using the reported eluent.