diethyl 2-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethyl)malonate

Base Information

Chemical Name:diethyl 2-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethyl)malonate
CAS No.:1403884-43-4
Molecular Formula:C₁₉H₁₉BrF₃NO₅
Molecular Weight:478.263
Hs Code.:

Synonyms:diethyl 2-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethyl)malonate

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Chemical Property of diethyl 2-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethyl)malonate

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Technology Process of diethyl 2-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethyl)malonate

There total 4 articles about diethyl 2-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 383-53-9
2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone

: 1403884-43-4
diethyl 2-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethyl)malonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 2 h / 130 °C

2.1: sodium tetrahydroborate / methanol / 2 h / Cooling with ice; Reflux

3.1: triethylamine / dichloromethane / 20 °C / Cooling with ice

4.1: N-Bromosuccinimide; acetic acid / 20 °C

5.1: potassium carbonate / methanol / 1 h / 20 °C

6.1: triethylamine / dichloromethane / 1 h

7.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Cooling with ice

7.2: 4 h / 65 °C

With sodium tetrahydroborate; N-Bromosuccinimide; sodium hydride; potassium carbonate; acetic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; mineral oil;

Reference yield:

: 1403883-96-4
ethyl 2-(4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)acetate

: 1403884-43-4
diethyl 2-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethyl)malonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate / methanol / 2 h / Cooling with ice; Reflux

2.1: triethylamine / dichloromethane / 20 °C / Cooling with ice

3.1: N-Bromosuccinimide; acetic acid / 20 °C

4.1: potassium carbonate / methanol / 1 h / 20 °C

5.1: triethylamine / dichloromethane / 1 h

6.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Cooling with ice

6.2: 4 h / 65 °C

With sodium tetrahydroborate; N-Bromosuccinimide; sodium hydride; potassium carbonate; acetic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; mineral oil;

Reference yield:

: 1403883-98-6
2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethyl acetate

: 1403884-43-4
diethyl 2-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethyl)malonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / methanol / 1 h / 20 °C

2.1: triethylamine / dichloromethane / 1 h

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Cooling with ice

3.2: 4 h / 65 °C

With sodium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; mineral oil;