2-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethyl)propane-1,3-diyl diacetate

Base Information

Chemical Name:2-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethyl)propane-1,3-diyl diacetate
CAS No.:1403881-96-8
Molecular Formula:C₂₆H₂₂BrF₅N₂O₇
Molecular Weight:649.366
Hs Code.:

Synonyms:2-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethyl)propane-1,3-diyl diacetate

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Chemical Property of 2-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethyl)propane-1,3-diyl diacetate

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Technology Process of 2-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethyl)propane-1,3-diyl diacetate

There total 8 articles about 2-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethyl)propane-1,3-diyl diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 951122-37-5
2,6-difluoro-3-hydroxy-benzamide

: 1403884-46-7
2-(2-bromo-2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethyl)propane-1,3-diyl diacetate

: 1403881-96-8
2-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethyl)propane-1,3-diyl diacetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 4h; Inert atmosphere;

Reference yield:

: 383-53-9
2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone

: 1403881-96-8
2-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethyl)propane-1,3-diyl diacetate

Guidance literature:: Multi-step reaction with 11 steps

1.1: 2 h / 130 °C

2.1: sodium tetrahydroborate / methanol / 2 h / Cooling with ice; Reflux

3.1: triethylamine / dichloromethane / 20 °C / Cooling with ice

4.1: N-Bromosuccinimide; acetic acid / 20 °C

5.1: potassium carbonate / methanol / 1 h / 20 °C

6.1: triethylamine / dichloromethane / 1 h

7.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Cooling with ice

7.2: 4 h / 65 °C

8.1: sodium tetrahydroborate / methanol / 3 h / 65 °C

8.2: Cooling with ice

9.1: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice

10.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux

11.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; potassium carbonate; acetic acid; triethylamine; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1403884-43-4
diethyl 2-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethyl)malonate

: 1403881-96-8
2-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethyl)propane-1,3-diyl diacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / methanol / 3 h / 65 °C

1.2: Cooling with ice

2.1: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice

3.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; triethylamine; In methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;