10-[2-(2-{2-[5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-ethoxy}-ethoxy)-ethoxy]-decanoic acid [(S)-1-{3-[4-(3-amino-propylamino)-butylamino]-propylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-amide

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Chemical Name:10-[2-(2-{2-[5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-ethoxy}-ethoxy)-ethoxy]-decanoic acid [(S)-1-{3-[4-(3-amino-propylamino)-butylamino]-propylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-amide
CAS No.:239115-59-4
Molecular Formula:C₄₅H₈₀N₈O₈S
Molecular Weight:893.245
Hs Code.:

10-[2-(2-{2-[5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-ethoxy}-ethoxy)-ethoxy]-decanoic acid [(S)-1-{3-[4-(3-amino-propylamino)-butylamino]-propylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-amide

Synonyms:10-[2-(2-{2-[5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-ethoxy}-ethoxy)-ethoxy]-decanoic acid [(S)-1-{3-[4-(3-amino-propylamino)-butylamino]-propylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-amide

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Chemical Property of 10-[2-(2-{2-[5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-ethoxy}-ethoxy)-ethoxy]-decanoic acid [(S)-1-{3-[4-(3-amino-propylamino)-butylamino]-propylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-amide

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Technology Process of 10-[2-(2-{2-[5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-ethoxy}-ethoxy)-ethoxy]-decanoic acid [(S)-1-{3-[4-(3-amino-propylamino)-butylamino]-propylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-amide

There total 17 articles about 10-[2-(2-{2-[5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-ethoxy}-ethoxy)-ethoxy]-decanoic acid [(S)-1-{3-[4-(3-amino-propylamino)-butylamino]-propylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 86520-52-7
2-[2-(2-azidoethoxy)ethoxy]ethanol

: 239115-59-4
10-[2-(2-{2-[5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-ethoxy}-ethoxy)-ethoxy]-decanoic acid [(S)-1-{3-[4-(3-amino-propylamino)-butylamino]-propylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 9 steps

1: 88 percent / Bu₄NBr, aq. NaOH / 5 h / 60 °C

2: 98 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH₂Cl₂; H₂O / 1 h

3: 79 percent / Dess-Martin reagent / CH₂Cl₂ / 1 h

4: 91 percent / NaClO₂, NaH₂PO₄, 2-methyl-2-butene / tetrahydrofuran; 2-methyl-propan-2-ol; H₂O / 0.5 h

5: 94 percent / 1-hydroxybenzotriazole, Et₃N, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 18 h

6: H₂ / Pd(OH)2/C / methanol / 1 h

7: Et₃N / CH₂Cl₂; tetrahydrofuran / 10 h

8: 75 percent / aq. NaOH / methanol / 4 h

9: 1.) p-nitrophenol, dicyclohexylcarbodiimide / 1.) THF, 12 h, 2.) THF, 2 h

With sodium hydroxide; sodium chlorite; sodium dihydrogenphosphate; 4-nitro-phenol; 2-methyl-but-2-ene; tetrabutylammomium bromide; hydrogen; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dicyclohexyl-carbodiimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/S0968-0896(99)00054-1

Reference yield:

: 112-47-0
1,10-Decanediol

: 239115-59-4
10-[2-(2-{2-[5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-ethoxy}-ethoxy)-ethoxy]-decanoic acid [(S)-1-{3-[4-(3-amino-propylamino)-butylamino]-propylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 12 steps

1: 55 percent / NaH / dimethylformamide / 6 h

2: 99 percent / Et₃N / CH₂Cl₂ / 1.) -78 deg C, 10 min, 2.) room temp., 1 h

3: 99 percent / NaI / acetone / 3 h / Heating

4: 88 percent / Bu₄NBr, aq. NaOH / 5 h / 60 °C

5: 98 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH₂Cl₂; H₂O / 1 h

6: 79 percent / Dess-Martin reagent / CH₂Cl₂ / 1 h

7: 91 percent / NaClO₂, NaH₂PO₄, 2-methyl-2-butene / tetrahydrofuran; 2-methyl-propan-2-ol; H₂O / 0.5 h

8: 94 percent / 1-hydroxybenzotriazole, Et₃N, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 18 h

9: H₂ / Pd(OH)2/C / methanol / 1 h

10: Et₃N / CH₂Cl₂; tetrahydrofuran / 10 h

11: 75 percent / aq. NaOH / methanol / 4 h

12: 1.) p-nitrophenol, dicyclohexylcarbodiimide / 1.) THF, 12 h, 2.) THF, 2 h

With sodium hydroxide; sodium chlorite; sodium dihydrogenphosphate; 4-nitro-phenol; 2-methyl-but-2-ene; tetrabutylammomium bromide; hydrogen; sodium hydride; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dicyclohexyl-carbodiimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium iodide; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;
DOI:10.1016/S0968-0896(99)00054-1

Reference yield:

: 1080-06-4
L-Tyr-OMe

: 239115-59-4
10-[2-(2-{2-[5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-ethoxy}-ethoxy)-ethoxy]-decanoic acid [(S)-1-{3-[4-(3-amino-propylamino)-butylamino]-propylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / 1-hydroxybenzotriazole, Et₃N, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 18 h

2: H₂ / Pd(OH)2/C / methanol / 1 h

3: Et₃N / CH₂Cl₂; tetrahydrofuran / 10 h

4: 75 percent / aq. NaOH / methanol / 4 h

5: 1.) p-nitrophenol, dicyclohexylcarbodiimide / 1.) THF, 12 h, 2.) THF, 2 h

With sodium hydroxide; 4-nitro-phenol; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dicyclohexyl-carbodiimide; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0968-0896(99)00054-1