N-(2-(cyclohexylamino)-1-(1H-indol-4-yl)-2-oxoethyl)-N-(4-methoxybenzyl)but-2-ynamide

Base Information

Chemical Name:N-(2-(cyclohexylamino)-1-(1H-indol-4-yl)-2-oxoethyl)-N-(4-methoxybenzyl)but-2-ynamide
CAS No.:1447524-97-1
Molecular Formula:C₂₈H₃₁N₃O₃
Molecular Weight:457.572
Hs Code.:

Synonyms:N-(2-(cyclohexylamino)-1-(1H-indol-4-yl)-2-oxoethyl)-N-(4-methoxybenzyl)but-2-ynamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-(cyclohexylamino)-1-(1H-indol-4-yl)-2-oxoethyl)-N-(4-methoxybenzyl)but-2-ynamide

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Technology Process of N-(2-(cyclohexylamino)-1-(1H-indol-4-yl)-2-oxoethyl)-N-(4-methoxybenzyl)but-2-ynamide

There total 1 articles about N-(2-(cyclohexylamino)-1-(1H-indol-4-yl)-2-oxoethyl)-N-(4-methoxybenzyl)but-2-ynamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1074-86-8
4-formyl indole

: 931-53-3
Cyclohexyl isocyanide

: 590-93-2
2-Butynoic acid

: 2393-23-9
4-methoxy-benzylamine

: 1447524-97-1
N-(2-(cyclohexylamino)-1-(1H-indol-4-yl)-2-oxoethyl)-N-(4-methoxybenzyl)but-2-ynamide

Guidance literature:: With methanol; sodium sulfate; at 50 ℃;
DOI:10.1039/c3cc42704h

Reference yield: 70.0%

: 1447524-97-1
N-(2-(cyclohexylamino)-1-(1H-indol-4-yl)-2-oxoethyl)-N-(4-methoxybenzyl)but-2-ynamide

: 1447525-19-0
(E)-N-cyclohexyl-3-ethylidene-5-(4-methoxybenzyl)-4-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indole-6-carboxamide

Guidance literature:: With indium(III) triflate; In 1,2-dichloro-ethane; at 100 ℃; for 3h; regioselective reaction; Inert atmosphere;
DOI:10.1039/c3cc42704h

Reference yield: 68.0%

: 1447524-97-1
N-(2-(cyclohexylamino)-1-(1H-indol-4-yl)-2-oxoethyl)-N-(4-methoxybenzyl)but-2-ynamide

: (Z)-N-cyclohexyl-6-(4-methoxybenzyl)-3-methyl-5-oxo-1,5,6,7-tetrahydroazocino[5,4,3-cd]indole-7-carboxamide

Guidance literature:: With [AuCl(IPr)]; silver(I) triflimide; In 1,2-dichloro-ethane; at 100 ℃; for 8h; regioselective reaction; Inert atmosphere;
DOI:10.1039/c3cc42704h