3-(6-(3-(4-chlorothiazol-2-yl)-3-oxopropyl)-1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

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Chemical Name:3-(6-(3-(4-chlorothiazol-2-yl)-3-oxopropyl)-1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile
CAS No.:1614251-87-4
Molecular Formula:C₂₁H₁₆ClN₅O₃S
Molecular Weight:453.909
Hs Code.:

Synonyms:3-(6-(3-(4-chlorothiazol-2-yl)-3-oxopropyl)-1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

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Chemical Property of 3-(6-(3-(4-chlorothiazol-2-yl)-3-oxopropyl)-1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

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Technology Process of 3-(6-(3-(4-chlorothiazol-2-yl)-3-oxopropyl)-1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

There total 8 articles about 3-(6-(3-(4-chlorothiazol-2-yl)-3-oxopropyl)-1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1614251-86-3
3-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)-N-methoxy-N-methylpropanamide

: 139670-03-4
2-bromo-4-chlorothiazole

: 1614251-87-4
3-(6-(3-(4-chlorothiazol-2-yl)-3-oxopropyl)-1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

Guidance literature:: With TurboGrignard; In tetrahydrofuran; at 20 ℃; for 0.666667h;

Reference yield:

: 1614251-85-2
methyl 3-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)propanoate

: 1614251-87-4
3-(6-(3-(4-chlorothiazol-2-yl)-3-oxopropyl)-1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: isopropylmagnesium bromide / tetrahydrofuran / 0.5 h / 20 °C

2: TurboGrignard / tetrahydrofuran / 0.67 h / 20 °C

With TurboGrignard; isopropylmagnesium bromide; In tetrahydrofuran;

Reference yield:

: 874-14-6,156398-76-4
1,3-dimethyluracil

: 1614251-87-4
3-(6-(3-(4-chlorothiazol-2-yl)-3-oxopropyl)-1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium tert-butylate / 2-methyltetrahydrofuran / 0.67 h / 0 - 30 °C / Inert atmosphere

2.1: sodium hydride; N-benzyl-N,N,N-triethylammonium chloride / tetrahydrofuran; mineral oil / 18 h / 20 °C

3.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 0.5 h / -78 °C

3.2: 1.5 h / -78 °C

4.1: potassium carbonate / acetic acid butyl ester; water / 1.5 h / 80 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 60 °C

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 96 h / 20 °C

7.1: isopropylmagnesium bromide / tetrahydrofuran / 0.5 h / 20 °C

8.1: TurboGrignard / tetrahydrofuran / 0.67 h / 20 °C

With TurboGrignard; n-butyllithium; potassium tert-butylate; tetrabutyl ammonium fluoride; N-benzyl-N,N,N-triethylammonium chloride; isopropylmagnesium bromide; sodium hydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; diisopropylamine; In tetrahydrofuran; 2-methyltetrahydrofuran; acetic acid butyl ester; water; acetonitrile; mineral oil;