methyl 3-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)propanoate

Base Information

Chemical Name:methyl 3-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)propanoate
CAS No.:1614251-85-2
Molecular Formula:C₁₉H₁₈N₄O₄
Molecular Weight:366.376
Hs Code.:

Synonyms:methyl 3-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)propanoate

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Chemical Property of methyl 3-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)propanoate

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Technology Process of methyl 3-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)propanoate

There total 6 articles about methyl 3-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613622-60-8
3-(1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 1614251-85-2
methyl 3-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)propanoate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃; for 96h;

Reference yield:

: 874-14-6,156398-76-4
1,3-dimethyluracil

: 1614251-85-2
methyl 3-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium tert-butylate / 2-methyltetrahydrofuran / 0.67 h / 0 - 30 °C / Inert atmosphere

2.1: sodium hydride; N-benzyl-N,N,N-triethylammonium chloride / tetrahydrofuran; mineral oil / 18 h / 20 °C

3.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 0.5 h / -78 °C

3.2: 1.5 h / -78 °C

4.1: potassium carbonate / acetic acid butyl ester; water / 1.5 h / 80 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 60 °C

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 96 h / 20 °C

With n-butyllithium; potassium tert-butylate; tetrabutyl ammonium fluoride; N-benzyl-N,N,N-triethylammonium chloride; sodium hydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; diisopropylamine; In tetrahydrofuran; 2-methyltetrahydrofuran; acetic acid butyl ester; water; acetonitrile; mineral oil;

Reference yield:

: 1613623-79-2
1,3-dimethyl-6-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

: 1614251-85-2
methyl 3-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 0.5 h / -78 °C

1.2: 1.5 h / -78 °C

2.1: potassium carbonate / acetic acid butyl ester; water / 1.5 h / 80 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 60 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 96 h / 20 °C

With n-butyllithium; tetrabutyl ammonium fluoride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; diisopropylamine; In tetrahydrofuran; acetic acid butyl ester; water; acetonitrile;