Technology Process of 4-chloro-3'-((2-cyclohexyl-1-oxoisoindolin-5-yloxy)methyl)biphenyl-3-carboxylic acid
There total 7 articles about 4-chloro-3'-((2-cyclohexyl-1-oxoisoindolin-5-yloxy)methyl)biphenyl-3-carboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
water; lithium hydroxide;
In
tetrahydrofuran;
at 80 ℃;
DOI:10.1021/jm1012165
- Guidance literature:
-
Multi-step reaction with 4 steps
1: toluene / 12 h / 110 °C / Molecular sieve; Inert atmosphere
2: acetic acid; zinc / 0.08 h / Reflux; Inert atmosphere
3: potassium carbonate / acetone / 60 °C / Inert atmosphere
4: water; lithium hydroxide / tetrahydrofuran / 80 °C
With
water; potassium carbonate; acetic acid; lithium hydroxide; zinc;
In
tetrahydrofuran; acetone; toluene;
DOI:10.1021/jm1012165
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium carbonate / acetone / 1 h / 50 °C / Inert atmosphere
2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 12 h / Reflux; Inert atmosphere
3: potassium carbonate / acetone / 60 °C / Inert atmosphere
4: water; lithium hydroxide / tetrahydrofuran / 80 °C
With
N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); water; potassium carbonate; lithium hydroxide;
In
tetrahydrofuran; tetrachloromethane; acetone;
DOI:10.1021/jm1012165