3-amino-N-[(R)-1-(4-fluoro-phenyl)-ethyl]-5-(2-isoquinolin-3-yl-3H-imidazol-4-yl)-benzamide

Base Information

Chemical Name:3-amino-N-[(R)-1-(4-fluoro-phenyl)-ethyl]-5-(2-isoquinolin-3-yl-3H-imidazol-4-yl)-benzamide
CAS No.:950225-65-7
Molecular Formula:C₂₇H₂₂FN₅O
Molecular Weight:451.503
Hs Code.:

Synonyms:3-amino-N-[(R)-1-(4-fluoro-phenyl)-ethyl]-5-(2-isoquinolin-3-yl-3H-imidazol-4-yl)-benzamide

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Chemical Property of 3-amino-N-[(R)-1-(4-fluoro-phenyl)-ethyl]-5-(2-isoquinolin-3-yl-3H-imidazol-4-yl)-benzamide

Chemical Property:

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Technology Process of 3-amino-N-[(R)-1-(4-fluoro-phenyl)-ethyl]-5-(2-isoquinolin-3-yl-3H-imidazol-4-yl)-benzamide

There total 1 articles about 3-amino-N-[(R)-1-(4-fluoro-phenyl)-ethyl]-5-(2-isoquinolin-3-yl-3H-imidazol-4-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-[(R)-1-(4-fluoro-phenyl)-ethyl]-3-(2-isoquinolin-3-yl-3H-imidazol-4-yl)-5-nitro-benzamide dihydrochloride

: 950225-65-7
3-amino-N-[(R)-1-(4-fluoro-phenyl)-ethyl]-5-(2-isoquinolin-3-yl-3H-imidazol-4-yl)-benzamide

Guidance literature:: With ammonium formate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; at 20 - 60 ℃; for 1.08333h;

Reference yield:

: 950225-65-7
3-amino-N-[(R)-1-(4-fluoro-phenyl)-ethyl]-5-(2-isoquinolin-3-yl-3H-imidazol-4-yl)-benzamide

: 152120-54-2,862686-58-6,1143572-00-2
N,N'-bis( tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine

: N-[(1R)-(4-Fluoro-phenyl)-ethyl]-3-guanidino-5-(2-isoquinolin-3-yl-3H-imidazol-4-yl)-benzamide Dihydrochloride

Guidance literature:: 3-amino-N-[(R)-1-(4-fluoro-phenyl)-ethyl]-5-(2-isoquinolin-3-yl-3H-imidazol-4-yl)-benzamide; N,N'-bis( tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine; With potassium carbonate; In 1,4-dioxane; at 90 ℃; for 0.5h; Microwave;

With hydrogenchloride; In 1,4-dioxane; dichloromethane; for 1h;

Reference yield:

: 950225-65-7
3-amino-N-[(R)-1-(4-fluoro-phenyl)-ethyl]-5-(2-isoquinolin-3-yl-3H-imidazol-4-yl)-benzamide

: 63812-15-7
2-fluoro-2-methylpropanoic acid

: 950225-19-1
N-[(1R)-1-(4-fluorophenyl)ethyl]-3-(2-isoquinoline-3-yl-1H-imidazol-4-yl)-5-(2-fluoroisobutyrylamino)benzamide

Guidance literature:: 3-amino-N-[(R)-1-(4-fluoro-phenyl)-ethyl]-5-(2-isoquinolin-3-yl-3H-imidazol-4-yl)-benzamide; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

2-fluoro-2-methylpropanoic acid; In N,N-dimethyl-formamide; at 0 ℃; for 6h;