(3S,5S)-5-{(S)-1-[(Z)-Benzyloxyimino]-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-3-isopropyl-dihydro-furan-2-one

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Chemical Name:(3S,5S)-5-{(S)-1-[(Z)-Benzyloxyimino]-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-3-isopropyl-dihydro-furan-2-one
CAS No.:325740-72-5
Molecular Formula:C₃₂H₄₅NO₆
Molecular Weight:539.712
Hs Code.:

Synonyms:(3S,5S)-5-{(S)-1-[(Z)-Benzyloxyimino]-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-3-isopropyl-dihydro-furan-2-one

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Chemical Property of (3S,5S)-5-{(S)-1-[(Z)-Benzyloxyimino]-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-3-isopropyl-dihydro-furan-2-one

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Technology Process of (3S,5S)-5-{(S)-1-[(Z)-Benzyloxyimino]-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-3-isopropyl-dihydro-furan-2-one

There total 14 articles about (3S,5S)-5-{(S)-1-[(Z)-Benzyloxyimino]-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-3-isopropyl-dihydro-furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 325740-64-5
(3S,5S)-3-Isopropyl-5-{(S)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentanoyl}-dihydro-furan-2-one

: 325740-72-5
(3S,5S)-5-{(S)-1-[(Z)-Benzyloxyimino]-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-3-isopropyl-dihydro-furan-2-one

Guidance literature:: With sodium hydrogencarbonate;
DOI:10.1016/S0040-4039(00)01794-9

Reference yield:

: 172900-71-9
(R)-3-[4-methoxy-3-(3-methoxypropoxy)phenyl]-2-(1-methylethyl)propanoic acid

: 325740-72-5
(3S,5S)-5-{(S)-1-[(Z)-Benzyloxyimino]-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-3-isopropyl-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / NaBH₄; I₂ / 96 h / 20 °C

2: 70 percent / SOCl₂; pyridine

3: Mg; BrCH₂CH₂Br / tetrahydrofuran / 20 °C

4: 89 percent / NaHCO₃

With pyridine; sodium tetrahydroborate; thionyl chloride; iodine; sodium hydrogencarbonate; magnesium; ethylene dibromide; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)01794-9

Reference yield:

: 145589-03-3,104266-90-2
(S)-4-benzyl-3-(3-methylbutanoyl)oxazolidin-2-one

: 325740-72-5
(3S,5S)-5-{(S)-1-[(Z)-Benzyloxyimino]-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-3-isopropyl-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 9 steps

1: 94 percent / LIHMDS / tetrahydrofuran / -78 °C

2: 88 percent / OsO₄; NMMO / 2-methyl-propan-2-ol; acetone; H₂O

3: NaIO₄; RuCl₃*H₂O / CCl₄; acetonitrile; H₂O / 6 h

4: (COCl)2 / dimethylformamide; toluene / 1 h

5: NEt₃ / CH₂Cl₂

6: 100 percent / H₂ / Pd/C / ethyl acetate

7: (COCl)2 / toluene; dimethylformamide / 1 h

8: Mg; BrCH₂CH₂Br / tetrahydrofuran / 20 °C

9: 89 percent / NaHCO₃

With ruthenium trichloride; sodium periodate; osmium(VIII) oxide; oxalyl dichloride; hydrogen; sodium hydrogencarbonate; magnesium; 4-methylmorpholine N-oxide; ethylene dibromide; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; tert-butyl alcohol;
DOI:10.1016/S0040-4039(00)01794-9