5-(tert-butyldimethylsilanyloxymethyl)-1-methyl-5-phenyl-3-pyrimidin-5-ylimidazolidine-2,4-dione

Base Information

• Chemical Name: 5-(tert-butyldimethylsilanyloxymethyl)-1-methyl-5-phenyl-3-pyrimidin-5-ylimidazolidine-2,4-dione
• CAS No.: 1401226-55-8
• Molecular Formula: C₂₁H₂₈N₄O₃Si
• Molecular Weight: 412.564

Synonyms:5-(tert-butyldimethylsilanyloxymethyl)-1-methyl-5-phenyl-3-pyrimidin-5-ylimidazolidine-2,4-dione

Chemical Property of 5-(tert-butyldimethylsilanyloxymethyl)-1-methyl-5-phenyl-3-pyrimidin-5-ylimidazolidine-2,4-dione

Chemical Property:

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Technology Process of 5-(tert-butyldimethylsilanyloxymethyl)-1-methyl-5-phenyl-3-pyrimidin-5-ylimidazolidine-2,4-dione

There total 2 articles about 5-(tert-butyldimethylsilanyloxymethyl)-1-methyl-5-phenyl-3-pyrimidin-5-ylimidazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

5-(tert-butyldimethylsilanyloxymethyl)-5-phenyl-3-pyrimidin-5-yl-imidazolidine-2,4-dione (1401226-52-5) + methyl iodide (74-88-4) → 5-(tert-butyldimethylsilanyloxymethyl)-1-methyl-5-phenyl-3-pyrimidin-5-ylimidazolidine-2,4-dione (1401226-55-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/jm300281x

Reference yield:

5-(tert-butyldimethylsilanyloxymethyl)-5-phenylimidazolidine-2,4-dione (1401226-49-0) → 5-(tert-butyldimethylsilanyloxymethyl)-1-methyl-5-phenyl-3-pyrimidin-5-ylimidazolidine-2,4-dione (1401226-55-8)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(I) oxide / N,N-dimethyl acetamide / 1.67 h / 160 °C / Microwave irradiation; Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

With copper(I) oxide; potassium carbonate; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;

DOI:10.1021/jm300281x

Reference yield: 77.0%

5-(tert-butyldimethylsilanyloxymethyl)-1-methyl-5-phenyl-3-pyrimidin-5-ylimidazolidine-2,4-dione (1401226-55-8) → 5-hydroxymethyl-1-methyl-5-phenyl-3-pyrimidin-5-ylimidazolidine-2,4-dione (1401226-58-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1021/jm300281x

upstream raw materials:

5-(tert-butyldimethylsilanyloxymethyl)-5-phenyl-3-pyrimidin-5-yl-imidazolidine-2,4-dione

methyl iodide

5-(tert-butyldimethylsilanyloxymethyl)-5-phenylimidazolidine-2,4-dione

Downstream raw materials:

5-hydroxymethyl-1-methyl-5-phenyl-3-pyrimidin-5-ylimidazolidine-2,4-dione

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