tert-butyl 3-(7-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-3-methyl-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1 pyrimidin-1(2H)-yl)phenylcarbamate

Base Information

Chemical Name:tert-butyl 3-(7-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-3-methyl-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1 pyrimidin-1(2H)-yl)phenylcarbamate
CAS No.:1363161-28-7
Molecular Formula:C₃₀H₃₈N₈O₄
Molecular Weight:574.683
Hs Code.:

tert-butyl 3-(7-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-3-methyl-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1 pyrimidin-1(2H)-yl)phenylcarbamate

Synonyms:tert-butyl 3-(7-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-3-methyl-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1 pyrimidin-1(2H)-yl)phenylcarbamate

Suppliers and Price of tert-butyl 3-(7-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-3-methyl-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1 pyrimidin-1(2H)-yl)phenylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl 3-(7-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-3-methyl-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1 pyrimidin-1(2H)-yl)phenylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 3-(7-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-3-methyl-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1 pyrimidin-1(2H)-yl)phenylcarbamate

There total 7 articles about tert-butyl 3-(7-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-3-methyl-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1 pyrimidin-1(2H)-yl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 122833-04-9
2-methoxy-4-(4-methylpiperazin-1-yl)aniline

: 1363161-19-6
tert-butyl 3-(3-methyl-7-(methylsulfonyl)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)phenylcarbamate

: 1363161-28-7
tert-butyl 3-(7-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-3-methyl-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1 pyrimidin-1(2H)-yl)phenylcarbamate

Guidance literature:: With trifluoroacetic acid; In iso-butanol; at 110 ℃; for 18h;
DOI:10.1021/jm201591k

Reference yield:

: 1363161-15-2
tert-butyl 3-(5-(hydroxymethyl)-2-(methylmercapto)pyrimidine-4-ylamino)phenylcarbamate

: 1363161-28-7
tert-butyl 3-(7-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-3-methyl-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1 pyrimidin-1(2H)-yl)phenylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1: manganese(IV) oxide / dichloromethane / 20 °C

2: sodium acetate / methanol / 1 h / 20 °C

3: sodium tetrahydroborate / methanol / 20 °C

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 - 20 °C

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 20 °C

6: trifluoroacetic acid / iso-butanol / 18 h / 110 °C

With manganese(IV) oxide; sodium tetrahydroborate; sodium acetate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; iso-butanol;
DOI:10.1021/jm201591k

Reference yield:

: 1363161-18-5
tert-butyl 3-(3-methyl-7-(methylthio)-2-oxo-3,4-dihydropyrimido[4,5-d] pyrimidin-1(2H)-yl) phenylcarbamate

: 1363161-28-7
tert-butyl 3-(7-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-3-methyl-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1 pyrimidin-1(2H)-yl)phenylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 20 °C

2: trifluoroacetic acid / iso-butanol / 18 h / 110 °C

With 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In dichloromethane; iso-butanol;
DOI:10.1021/jm201591k