2'-[(2-methylamino-ethylamino)-methyl]-4'-oxazol-2-yl-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-(2-methoxy-ethoxymethyl)-amide

Base Information

• Chemical Name: 2'-[(2-methylamino-ethylamino)-methyl]-4'-oxazol-2-yl-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-(2-methoxy-ethoxymethyl)-amide
• CAS No.: 195447-68-8
• Molecular Formula: C₂₈H₃₅N₅O₆S
• Molecular Weight: 569.682
• Mol file: 195447-68-8.mol

Synonyms:2'-[(2-methylamino-ethylamino)-methyl]-4'-oxazol-2-yl-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-(2-methoxy-ethoxymethyl)-amide

Chemical Property of 2'-[(2-methylamino-ethylamino)-methyl]-4'-oxazol-2-yl-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-(2-methoxy-ethoxymethyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-[(2-methylamino-ethylamino)-methyl]-4'-oxazol-2-yl-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-(2-methoxy-ethoxymethyl)-amide

There total 4 articles about 2'-[(2-methylamino-ethylamino)-methyl]-4'-oxazol-2-yl-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-(2-methoxy-ethoxymethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2'-{[(Z)-2-Methylamino-ethylimino]-methyl}-4'-oxazol-2-yl-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-(2-methoxy-ethoxymethyl)-amide → 2'-[(2-methylamino-ethylamino)-methyl]-4'-oxazol-2-yl-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-(2-methoxy-ethoxymethyl)-amide (195447-68-8)

Guidance literature:

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/jm020289q

Reference yield:

N-(3,4-Dimethyl-5-isoxazolyl)-2'-formyl-N-[(2-methoxyethoxy)methyl]-4'-(2-oxazolyl)-[1,1'-biphenyl]-2-sulfonamide (176961-44-7) → 2'-[(2-methylamino-ethylamino)-methyl]-4'-oxazol-2-yl-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-(2-methoxy-ethoxymethyl)-amide (195447-68-8)

Guidance literature:

Multi-step reaction with 4 steps

1: NaBH₄ / methanol / 2.5 h / 0 °C

2: 165 mg / CBr₄; PPh₃ / dimethylformamide / 2.5 h / 0 °C

3: 3A molecular sieves; AcOH / CH₂Cl₂ / 0.17 h

4: Na(AcO)3BH / CH₂Cl₂ / 12 h / 20 °C

With sodium tetrahydroborate; carbon tetrabromide; 3 A molecular sieve; sodium tris(acetoxy)borohydride; acetic acid; triphenylphosphine; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm020289q

Reference yield:

2'-hydroxymethyl-4'-oxazol-2-yl-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-(2-methoxy-ethoxymethyl)-amide (195447-19-9) → 2'-[(2-methylamino-ethylamino)-methyl]-4'-oxazol-2-yl-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-(2-methoxy-ethoxymethyl)-amide (195447-68-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 165 mg / CBr₄; PPh₃ / dimethylformamide / 2.5 h / 0 °C

2: 3A molecular sieves; AcOH / CH₂Cl₂ / 0.17 h

3: Na(AcO)3BH / CH₂Cl₂ / 12 h / 20 °C

With carbon tetrabromide; 3 A molecular sieve; sodium tris(acetoxy)borohydride; acetic acid; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm020289q

upstream raw materials:

N-(3,4-Dimethyl-5-isoxazolyl)-2'-formyl-N-[(2-methoxyethoxy)methyl]-4'-(2-oxazolyl)-[1,1'-biphenyl]-2-sulfonamide

2'-hydroxymethyl-4'-oxazol-2-yl-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-(2-methoxy-ethoxymethyl)-amide

2'-(bromomethyl)-N-(3,4-dimethyl-5-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide

Downstream raw materials:

N-(3,4-Dimethyl-5-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-2'-[(3-methyl-2-oxo-1-imidazolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide