Technology Process of (S)-3,3,3-trifluoro-2-(3-(methylthio)phenyl)propane-1,2-diol
There total 1 articles about (S)-3,3,3-trifluoro-2-(3-(methylthio)phenyl)propane-1,2-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / tetrahydrofuran; water / 20 - 60 °C / Sealed tube
2: AD-mix-α: / water; tert-butyl alcohol / 48 h / 0 °C
With
tetrakis(triphenylphosphine) palladium(0); AD-mix-α:; sodium carbonate;
In
tetrahydrofuran; water; tert-butyl alcohol;
1: Suzuki coupling / 2: Sharpless dihydroxylation;
DOI:10.1021/jo200958a
- Guidance literature:
-
(S)-3,3,3-trifluoro-2-(3-(methylthio)phenyl)propane-1,2-diol;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 0 ℃;
for 0.0833333h;
With
p-toluenesulfonyl chloride;
In
tetrahydrofuran; mineral oil;
at 0 ℃;
for 3h;
With
sodium hydroxide;
In
tetrahydrofuran; mineral oil;
at 0 ℃;
for 0.0833333h;
DOI:10.1021/jo200958a
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 0 °C
1.2: 3 h / 0 °C
1.3: 0.08 h / 0 °C
2.1: lithium aluminium tetrahydride / diethyl ether / 0.5 h / 0 °C
With
lithium aluminium tetrahydride; sodium hydride;
In
tetrahydrofuran; diethyl ether; mineral oil;
DOI:10.1021/jo200958a
