3-[2-(3-hydroxy-4-methoxyphenyl)oxazol-4-yl]-1-(3-methylpyridin-2-yl)propan-1-one

Base Information

Chemical Name:3-[2-(3-hydroxy-4-methoxyphenyl)oxazol-4-yl]-1-(3-methylpyridin-2-yl)propan-1-one
CAS No.:937779-90-3
Molecular Formula:C₁₉H₁₈N₂O₄
Molecular Weight:338.363
Hs Code.:

Synonyms:3-[2-(3-hydroxy-4-methoxyphenyl)oxazol-4-yl]-1-(3-methylpyridin-2-yl)propan-1-one

Suppliers and Price of 3-[2-(3-hydroxy-4-methoxyphenyl)oxazol-4-yl]-1-(3-methylpyridin-2-yl)propan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-[2-(3-hydroxy-4-methoxyphenyl)oxazol-4-yl]-1-(3-methylpyridin-2-yl)propan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-[2-(3-hydroxy-4-methoxyphenyl)oxazol-4-yl]-1-(3-methylpyridin-2-yl)propan-1-one

There total 8 articles about 3-[2-(3-hydroxy-4-methoxyphenyl)oxazol-4-yl]-1-(3-methylpyridin-2-yl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl 2-[2-(3-benzyloxy-4-methoxyphenyl)oxazol-4-ylmethyl]-3-(3-methylpyridin-2-yl)-3-oxopropionate

: 937779-90-3
3-[2-(3-hydroxy-4-methoxyphenyl)oxazol-4-yl]-1-(3-methylpyridin-2-yl)propan-1-one

Guidance literature:: With hydrogenchloride; In ethanol; water; at 80 ℃; for 1.5h;

Reference yield:

: 1574285-74-7
C₁₈H₁₆BrNO₃

: 1248195-40-5
ethyl 3-(3-methylpyridin-2-yl)-3-oxopropanoate

: 937779-90-3
3-[2-(3-hydroxy-4-methoxyphenyl)oxazol-4-yl]-1-(3-methylpyridin-2-yl)propan-1-one

Guidance literature:: C₁₈H₁₆BrNO₃; ethyl 3-(3-methylpyridin-2-yl)-3-oxopropanoate; With potassium carbonate; In N,N-dimethyl-formamide; for 2h; Cooling with ice;

With hydrogen bromide; In methanol; water; ethyl acetate; for 2h; Reflux;

Reference yield:

: 645-08-9,74309-78-7
Isovanillic acid

: 937779-90-3
3-[2-(3-hydroxy-4-methoxyphenyl)oxazol-4-yl]-1-(3-methylpyridin-2-yl)propan-1-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: thionyl chloride / 2 h / Reflux

2.1: tetrabutyl-ammonium chloride; potassium carbonate / water; toluene / 2 h / 80 °C

2.2: 2 h / Reflux

3.1: thionyl chloride; 1-methyl-pyrrolidin-2-one / toluene / 3 h / 20 °C

4.1: ammonium hydroxide / water; toluene; 1-methyl-pyrrolidin-2-one / Cooling with ice

5.1: bromine / 1,2-dimethoxyethane / 1 h / 60 °C

5.2: 8 h / Reflux

6.1: zinc(II) chloride; sodium tetrahydroborate / 1,2-dimethoxyethane / 5 h / 50 °C

7.1: methanesulfonyl chloride / acetone / 1 h / Cooling with ice

7.2: 2 h

8.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / Cooling with ice

8.2: 2 h / Reflux

With 1-methyl-pyrrolidin-2-one; ammonium hydroxide; sodium tetrahydroborate; thionyl chloride; tetrabutyl-ammonium chloride; bromine; potassium carbonate; methanesulfonyl chloride; zinc(II) chloride; In 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; acetone; toluene;