2-[4-chloro-3-(4-fluorophenyl)-5-phenyl-pyrazolo[3,4-c]pyridazin-1-yl]-1-[(3R)-3-fluoropyrrolidin-1-yl]ethanone

Base Information

Chemical Name:2-[4-chloro-3-(4-fluorophenyl)-5-phenyl-pyrazolo[3,4-c]pyridazin-1-yl]-1-[(3R)-3-fluoropyrrolidin-1-yl]ethanone
CAS No.:1606126-23-1
Molecular Formula:C₂₃H₁₈ClF₂N₅O
Molecular Weight:453.879
Hs Code.:

Synonyms:2-[4-chloro-3-(4-fluorophenyl)-5-phenyl-pyrazolo[3,4-c]pyridazin-1-yl]-1-[(3R)-3-fluoropyrrolidin-1-yl]ethanone

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Chemical Property of 2-[4-chloro-3-(4-fluorophenyl)-5-phenyl-pyrazolo[3,4-c]pyridazin-1-yl]-1-[(3R)-3-fluoropyrrolidin-1-yl]ethanone

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Technology Process of 2-[4-chloro-3-(4-fluorophenyl)-5-phenyl-pyrazolo[3,4-c]pyridazin-1-yl]-1-[(3R)-3-fluoropyrrolidin-1-yl]ethanone

There total 6 articles about 2-[4-chloro-3-(4-fluorophenyl)-5-phenyl-pyrazolo[3,4-c]pyridazin-1-yl]-1-[(3R)-3-fluoropyrrolidin-1-yl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1606126-42-4
2-(4-chloro-3-iodo-5-phenyl-pyrazolo[3,4-c]pyridazin-1-yl)-1-[(3R)-3-fluoropyrrolidin-1-yl]ethanone

: 1765-93-1
4-fluoroboronic acid

: 1606126-23-1
2-[4-chloro-3-(4-fluorophenyl)-5-phenyl-pyrazolo[3,4-c]pyridazin-1-yl]-1-[(3R)-3-fluoropyrrolidin-1-yl]ethanone

Guidance literature:: 2-(4-chloro-3-iodo-5-phenyl-pyrazolo[3,4-c]pyridazin-1-yl)-1-[(3R)-3-fluoropyrrolidin-1-yl]ethanone; 4-fluoroboronic acid; With potassium phosphate; In water; N,N-dimethyl-formamide; for 0.333333h; Inert atmosphere;

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; N,N-dimethyl-formamide; at 60 ℃; for 0.5h; Sealed tube; Microwave irradiation;

Reference yield:

: 1606126-38-8
N-(4-(phenylethynyl)-1H-pyrazol-5-yl)acetamide

: 1606126-23-1
2-[4-chloro-3-(4-fluorophenyl)-5-phenyl-pyrazolo[3,4-c]pyridazin-1-yl]-1-[(3R)-3-fluoropyrrolidin-1-yl]ethanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / dichloromethane; water; 1,4-dioxane / 1 h / 20 °C

2.1: sodium hydroxide; water / ethanol / 4 h / 75 °C

3.1: sodium nitrite; hydrogenchloride / water / 24 h / -10 - 20 °C

4.1: N-iodo-succinimide / acetonitrile / 24 h / Reflux

5.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 16 h / 20 °C

6.1: potassium phosphate / water; N,N-dimethyl-formamide / 0.33 h / Inert atmosphere

6.2: 0.5 h / 60 °C / Sealed tube; Microwave irradiation

With hydrogenchloride; potassium phosphate; N-iodo-succinimide; water; sodium hydride; sodium hydroxide; sodium nitrite; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 1606126-39-9
1-(1-ethoxyethyl)-4-(phenylethynyl)-1H-pyrazol-5-amine

: 1606126-23-1
2-[4-chloro-3-(4-fluorophenyl)-5-phenyl-pyrazolo[3,4-c]pyridazin-1-yl]-1-[(3R)-3-fluoropyrrolidin-1-yl]ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium nitrite; hydrogenchloride / water / 24 h / -10 - 20 °C

2.1: N-iodo-succinimide / acetonitrile / 24 h / Reflux

3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 16 h / 20 °C

4.1: potassium phosphate / water; N,N-dimethyl-formamide / 0.33 h / Inert atmosphere

4.2: 0.5 h / 60 °C / Sealed tube; Microwave irradiation

With hydrogenchloride; potassium phosphate; N-iodo-succinimide; sodium hydride; sodium nitrite; In water; N,N-dimethyl-formamide; acetonitrile; mineral oil;