2-(4-chloro-3-iodo-5-phenyl-pyrazolo[3,4-c]pyridazin-1-yl)-1-[(3R)-3-fluoropyrrolidin-1-yl]ethanone

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Chemical Name:2-(4-chloro-3-iodo-5-phenyl-pyrazolo[3,4-c]pyridazin-1-yl)-1-[(3R)-3-fluoropyrrolidin-1-yl]ethanone
CAS No.:1606126-42-4
Molecular Formula:C₁₇H₁₄ClFIN₅O
Molecular Weight:485.687
Hs Code.:

Synonyms:2-(4-chloro-3-iodo-5-phenyl-pyrazolo[3,4-c]pyridazin-1-yl)-1-[(3R)-3-fluoropyrrolidin-1-yl]ethanone

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Chemical Property of 2-(4-chloro-3-iodo-5-phenyl-pyrazolo[3,4-c]pyridazin-1-yl)-1-[(3R)-3-fluoropyrrolidin-1-yl]ethanone

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Technology Process of 2-(4-chloro-3-iodo-5-phenyl-pyrazolo[3,4-c]pyridazin-1-yl)-1-[(3R)-3-fluoropyrrolidin-1-yl]ethanone

There total 5 articles about 2-(4-chloro-3-iodo-5-phenyl-pyrazolo[3,4-c]pyridazin-1-yl)-1-[(3R)-3-fluoropyrrolidin-1-yl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1606126-41-3
4-chloro-3-iodo-5-phenyl-1H-pyrazolo[3,4-c]pyridazine

: 1606126-43-5
2-chloro-1-[(3R)-3-fluoropyrrolidin-1-yl]ethanone

: 1606126-42-4
2-(4-chloro-3-iodo-5-phenyl-pyrazolo[3,4-c]pyridazin-1-yl)-1-[(3R)-3-fluoropyrrolidin-1-yl]ethanone

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 16h;

Reference yield:

: 1606126-38-8
N-(4-(phenylethynyl)-1H-pyrazol-5-yl)acetamide

: 1606126-42-4
2-(4-chloro-3-iodo-5-phenyl-pyrazolo[3,4-c]pyridazin-1-yl)-1-[(3R)-3-fluoropyrrolidin-1-yl]ethanone

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / dichloromethane; water; 1,4-dioxane / 1 h / 20 °C

2: sodium hydroxide; water / ethanol / 4 h / 75 °C

3: sodium nitrite; hydrogenchloride / water / 24 h / -10 - 20 °C

4: N-iodo-succinimide / acetonitrile / 24 h / Reflux

5: sodium hydride / mineral oil; N,N-dimethyl-formamide / 16 h / 20 °C

With hydrogenchloride; N-iodo-succinimide; water; sodium hydride; sodium hydroxide; sodium nitrite; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 1606126-39-9
1-(1-ethoxyethyl)-4-(phenylethynyl)-1H-pyrazol-5-amine

: 1606126-42-4
2-(4-chloro-3-iodo-5-phenyl-pyrazolo[3,4-c]pyridazin-1-yl)-1-[(3R)-3-fluoropyrrolidin-1-yl]ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: sodium nitrite; hydrogenchloride / water / 24 h / -10 - 20 °C

2: N-iodo-succinimide / acetonitrile / 24 h / Reflux

3: sodium hydride / mineral oil; N,N-dimethyl-formamide / 16 h / 20 °C

With hydrogenchloride; N-iodo-succinimide; sodium hydride; sodium nitrite; In water; N,N-dimethyl-formamide; acetonitrile; mineral oil;