C₄₈H₅₇N₃O₁₆

Base Information

• Chemical Name: C₄₈H₅₇N₃O₁₆
• CAS No.: 1426832-55-4
• Molecular Formula: C₄₈H₅₇N₃O₁₆
• Molecular Weight: 931.991
• Mol file: 1426832-55-4.mol

Synonyms:C₄₈H₅₇N₃O₁₆

Chemical Property of C₄₈H₅₇N₃O₁₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₈H₅₇N₃O₁₆

There total 4 articles about C₄₈H₅₇N₃O₁₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

Fmoc-(tBu)Asp-OH (71989-14-5) + (2S,3R)-2-Amino-3-((2S,3R,4R,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-3-acetylamino-tetrahydro-pyran-2-yloxy)-butyric acid benzyl ester (100938-57-6) → C48H57N3O16 (1426832-55-4)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 15h;

DOI:10.1016/j.bmc.2013.01.027

Reference yield:

N-(9H-fluorene-9-yl)-methoxycarbonyl-O-(3,4,6-tri-O-acetyl-2-azido-2-deoxy-α-D-galactopyranosyl)-L-threonine benzyl ester (100938-55-4) → C48H57N3O16 (1426832-55-4)

Guidance literature:

Multi-step reaction with 3 steps

1: zinc; acetic acid; copper(II) sulfate / tetrahydrofuran; water / 2 h / 20 °C

2: piperidine / N,N-dimethyl-formamide / 1 h / 20 °C

3: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 15 h / 20 °C

With piperidine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; copper(II) sulfate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2013.01.027

Reference yield:

Nα-fluoren-9-ylmethoxycarbonyl-O-(2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-α-D-galactopyranosyl)-L-threoninebenzyl ester (100938-56-5) → C48H57N3O16 (1426832-55-4)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine / N,N-dimethyl-formamide / 1 h / 20 °C

2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 15 h / 20 °C

With piperidine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2013.01.027

upstream raw materials:

3,4,6-tri-O-acetyl-2-azido-2-deoxy-alpha-D-galactopyranosyl chloride

Fmoc-(tBu)Asp-OH

(2S,3R)-2-Amino-3-((2S,3R,4R,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-3-acetylamino-tetrahydro-pyran-2-yloxy)-butyric acid benzyl ester

N-(9H-fluorene-9-yl)-methoxycarbonyl-O-(3,4,6-tri-O-acetyl-2-azido-2-deoxy-α-D-galactopyranosyl)-L-threonine benzyl ester

Downstream raw materials:

C₂₀H₃₃N₃O₁₀

c[L-aspartyl-O-(2-acetamido-2-deoxy-α-D-galactopyranosyl)-L-threonyl]

Refernces