3',5'-di-O-benzyl-3-N-(benzyloxymethyl)-4'-C-(hydroxymethyl)-3'-C-((methoxymethoxy)methyl)thymidine

Base Information

• Chemical Name: 3',5'-di-O-benzyl-3-N-(benzyloxymethyl)-4'-C-(hydroxymethyl)-3'-C-((methoxymethoxy)methyl)thymidine
• CAS No.: 583843-95-2
• Molecular Formula: C₃₆H₄₂N₂O₉
• Molecular Weight: 646.737

Synonyms:3',5'-di-O-benzyl-3-N-(benzyloxymethyl)-4'-C-(hydroxymethyl)-3'-C-((methoxymethoxy)methyl)thymidine

Chemical Property of 3',5'-di-O-benzyl-3-N-(benzyloxymethyl)-4'-C-(hydroxymethyl)-3'-C-((methoxymethoxy)methyl)thymidine

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Technology Process of 3',5'-di-O-benzyl-3-N-(benzyloxymethyl)-4'-C-(hydroxymethyl)-3'-C-((methoxymethoxy)methyl)thymidine

There total 16 articles about 3',5'-di-O-benzyl-3-N-(benzyloxymethyl)-4'-C-(hydroxymethyl)-3'-C-((methoxymethoxy)methyl)thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

benzyl bromide (100-39-0) + 3'-O-benzyl-3-N-(benzyloxymethyl)-4'-C-(hydroxymethyl)-3'-C-((methoxymethoxy)methyl)thymidine (583843-94-1) → 3',5'-di-O-benzyl-3-N-(benzyloxymethyl)-4'-C-(hydroxymethyl)-3'-C-((methoxymethoxy)methyl)thymidine (583843-95-2)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃;

DOI:10.1016/j.tetlet.2004.04.082

Reference yield: 49.0%

benzyl bromide (100-39-0) + 3'-O-benzyl-3-N-(benzyloxymethyl)-4'-C-(hydroxymethyl)-3'-C-((methoxymethoxy)methyl)thymidine (583843-94-1) → 3'-O-benzyl-4'-C,3-N-di(benzyloxymethyl)-3'-C-((methoxymethoxy)methyl)thymidine + 3',5'-di-O-benzyl-3-N-(benzyloxymethyl)-4'-C-(hydroxymethyl)-3'-C-((methoxymethoxy)methyl)thymidine (583843-95-2)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 2.5h;

DOI:10.1016/j.tet.2007.06.040

Reference yield: 42.0%

C36H40N2O9 → 3'-O-benzyl-4'-C,3-N-di(benzyloxymethyl)-3'-C-((methoxymethoxy)methyl)thymidine + 3',5'-di-O-benzyl-3-N-(benzyloxymethyl)-4'-C-(hydroxymethyl)-3'-C-((methoxymethoxy)methyl)thymidine (583843-95-2)

Guidance literature:

With triethylsilane; tin(IV) chloride;

DOI:10.1016/j.tet.2007.06.040

upstream raw materials:

benzyl bromide

3'-O-benzyl-3-N-(benzyloxymethyl)-4'-C-(hydroxymethyl)-3'-C-((methoxymethoxy)methyl)thymidine

C₅₇H₆₀N₂O₁₁

C₅₀H₅₄N₂O₁₁

Downstream raw materials:

3',5'-di-O-benzyl-3-N-(benzyloxymethyl)-3'-C-((methoxymethoxy)methyl)-4'-C-(p-toluenesulfonyloxymethyl)thymidine

3',5'-di-O-benzyl-3-N-(benzyloxymethyl)-3'-C-(hydroxymethyl)-4'-C-(p-toluenesulfonyloxymethyl)thymidine

C₄₁H₄₂N₂O₁₀S

3',5'-di-O-benzyl-3-N-(benzyloxymethyl)-3'-C-(2-methoxyethenyl)-4'-C-(p-toluenesulfonyloxymethyl)thymidine

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