(R)-3-(8-(4-fluoro-3-methylphenyl)octanoyl)-4-isopropyloxazolidin-2-one

Base Information

Chemical Name:(R)-3-(8-(4-fluoro-3-methylphenyl)octanoyl)-4-isopropyloxazolidin-2-one
CAS No.:1043890-97-6
Molecular Formula:C₂₁H₃₀FNO₃
Molecular Weight:363.473
Hs Code.:

Synonyms:(R)-3-(8-(4-fluoro-3-methylphenyl)octanoyl)-4-isopropyloxazolidin-2-one

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Chemical Property of (R)-3-(8-(4-fluoro-3-methylphenyl)octanoyl)-4-isopropyloxazolidin-2-one

Chemical Property:

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Technology Process of (R)-3-(8-(4-fluoro-3-methylphenyl)octanoyl)-4-isopropyloxazolidin-2-one

There total 4 articles about (R)-3-(8-(4-fluoro-3-methylphenyl)octanoyl)-4-isopropyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1043453-96-8
8-(4-fluoro-3-methylphenyl)octanoic acid

: 95530-58-8
(R)-4-isopropyloxazolidin-2-one

: 1043890-97-6
(R)-3-(8-(4-fluoro-3-methylphenyl)octanoyl)-4-isopropyloxazolidin-2-one

Guidance literature:: 8-(4-fluoro-3-methylphenyl)octanoic acid; With pivaloyl chloride; triethylamine; In tetrahydrofuran; at -10 ℃; for 1h;

(R)-4-isopropyloxazolidin-2-one; With lithium chloride; In tetrahydrofuran; at -10 - 20 ℃;

Reference yield:

: 30515-28-7
7-bromoheptanoic acid

: 1043890-97-6
(R)-3-(8-(4-fluoro-3-methylphenyl)octanoyl)-4-isopropyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 63 h / Heating / reflux

2.1: potassium tert-butylate / tetrahydrofuran; benzene / 1 h / Heating / reflux

2.2: 63 h / Heating / reflux

2.3: 20 °C / pH 2

3.1: hydrogen / palladium 10% on activated carbon / methanol / 63 h / 20 °C / 760.05 Torr

4.1: pivaloyl chloride; triethylamine / tetrahydrofuran / 1 h / -10 °C

4.2: -10 - 20 °C

With potassium tert-butylate; hydrogen; pivaloyl chloride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; toluene; benzene;

Reference yield:

: 1043453-95-7
8-(4-fluoro-3-methylphenyl)oct-7-enoic acid

: 1043890-97-6
(R)-3-(8-(4-fluoro-3-methylphenyl)octanoyl)-4-isopropyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 63 h / 20 °C / 760.05 Torr

2.1: pivaloyl chloride; triethylamine / tetrahydrofuran / 1 h / -10 °C

2.2: -10 - 20 °C

With hydrogen; pivaloyl chloride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol;