95530-58-8

Basic information

• Product Name: (R)-(+)-4-Isopropyl-2-oxazolidinone
• Synonyms: (R)-(+)-4-ISOPROPYL-2-OXAZOLIDINONE;(R)-4-ISOPROPYL-2-OXAZOLIDINONE;(4R)-4-ISOPROPYL-1,3-OXAZOLIDIN-2-ONE;(4R)-(+)-4-ISOPROPYL-2-OXAZOLIDINONE;(4R)-(+)-ISOPROPYL-2-OXAZOLIDINONE;4-R-ISOPROPYL-OXAZOLIDIN-2-ONE;(R)-(+)-4-ISOPROPYL-2-OXAZOLIDINONE, 99% (99% EE/GLC);(R)-Isopropyloxazolidinone
• CAS NO: 95530-58-8
• Molecular Formula: C₆H₁₁NO₂
• Molecular Weight: 129.16
• Product Categories: Oxazolidinone;chiral;Asymmetric Synthesis;Chiral Building Blocks;Glycidyl Compounds, etc. (Chiral);Synthetic Organic Chemistry;Peptide;Asymmetric Synthesis;Chiral Auxiliaries;Oxazolidinone Derivatives;Pyrazoles,Pyrazines
• Mol File: 95530-58-8.mol
• Article Data: 35

Chemical Properties

• Melting Point: 70-73 °C
• Boiling Point: 239.22°C (rough estimate)
• Flash Point: 129.9 °C
• Appearance: White/Crystalline Powder
• Density: 1.04 g/cm3
• Vapor Pressure: 0.00198mmHg at 25°C
• Refractive Index: 1.4300 (estimate)
• Storage Temp.: 0-6°C
• Solubility: very faint turbidity in EtOH
• PKA: 12.72±0.40(Predicted)
• Water Solubility: Soluble
• BRN: 5376658
• CAS DataBase Reference: (R)-(+)-4-Isopropyl-2-oxazolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-4-Isopropyl-2-oxazolidinone(95530-58-8)
• EPA Substance Registry System: (R)-(+)-4-Isopropyl-2-oxazolidinone(95530-58-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25-36-26
• WGK Germany: 3
• F: 3
• Hazardous Substances Data: 95530-58-8(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powde

InChI:InChI=1/C6H11NO2/c1-4(2)5-3-9-6(8)7-5/h4-5H,3H2,1-2H3,(H,7,8)/t5-/m0/s1

Upstream product

• 16369-05-4 valinol 
• 201230-82-2 carbon monoxide 
• 105-58-8 Diethyl carbonate 
• 57-13-6 urea 
• 17016-83-0 4-isopropyloxazolidin-2-one 
• 4276-09-9 (R)-2-amino-3-methylbutanol 
• 124-38-9 carbon dioxide 
• 851913-12-7 pentafluorophenyl (S)-2-(4-isobutylphenyl)propionate 
• 591-07-1 acetylurea 
• 640-68-6 D-Val-OH 
• 136314-65-3 N-Methyloxycarbonyl-D-valinol 
• 142618-88-0 (4R, 5S)-5-(1,2-bis(isopropoxycarbonyl)hydrazino)-4-isopropyl-2-oxazolidinone 
• 464157-77-5 benzyl (R)-(4-isopropyl-2-oxo-3-oxooxazolidin-3-yl)carbamate 
• 590-86-3 isovaleraldehyde 

Downstream Products

• 17016-83-0 (4S)-4-isopropyl-1,3-oxazolidin-2-one 
• 96837-44-4 (R)-4-isopropyl-3-(3-phenylpropanoyl)oxazolidin-2-one 
• 103422-95-3 (R)-4-isopropyl-3-(2-phenylacetyl)oxazolidin-2-one 
• 677031-97-9 (Z,4R)-4-isopropyl-3-(3'-methyl-2'-phenylbut-1'-enyl)oxazolidin-2-one 
• 868632-19-3 (4R)-3-(3-{[(tert-butoxy)carbonyl]amino}-1-oxopropyl)-4-(1-methylethyl)oxazolidin-2-one 
• 762297-73-4 (4R)-3-[(4-fluorophenyl)acetyl]-4-isopropyl-1,3-oxazolidin-2-one 
• 214492-01-0 (4S,2'S)-4-isopropyl-3-(2'-phenylpropanoyl)oxazolidin-2-one 
• 311310-18-6 (4S,2'R)-4-iso-propyl-3-(2'-phenylpropionyl)oxazolidin-2-one 
• 136436-80-1 (4S)-3-<(s'S)-2'-(4-isobutylphenyl)propanoyl>-4-(1-methylethyl)-2-oxazolidinone 
• 1464787-95-8 (E)-3-(1,2-difluoro-4-phenyl-but-1-en-3-ynyl)-4-isopropyloxazolidin-2-one 
• 1464787-96-9 (E)-3-(1,2-difluoro-4-p-tolylbut-1-en-3-ynyl)-4-isopropyloxazolidin-2-one 
• 1464787-97-0 (E)-3-(1,2-difluoro-4-(4-methoxyphenyl)but-1-en-3-ynyl)-4-isopropyloxazolidin-2-one 
• 1464787-98-1 (E)-3-(1,2-difluoro-4-m-tolylbut-1-en-3-ynyl)-4-isopropyloxazolidin-2-one 

Relevant articles and documents

Simple preparation method of N-acyl compound

The invention relates to a simple preparation method of an N-acyl compound. The simple preparation method comprises the specific steps that an amine compound and R-OCF3 are mixed in a solvent and react for 1 min-48 h at -80-100 DEG C, after the reaction is completed, water is added for quenching, and column separation and purification or recrystallization and purification are carried out to obtainthe N-acyl compound. According to the simple preparation method of the N-acyl compound, the characteristic that a substance containing trifluorooxygen groups can be decomposed in situ to produce fluorophosgene is utilized, and the substance directly reacts with the amine compound to achieve rapid N-carbonylation of an amines substrate and efficiently prepare a urea derivative and a carbamyl fluoride compound. The simple preparation method of the N-acyl compound has the advantages that the operation is simple, the reaction time is short, the application range of the substrate is wide, no catalysts or additives need to be used, the raw materials are easy to obtain, the product yield is high, the purification is easy, and the required compound can be obtained by using a column chromatographyisolation method or recrystallization.

Synthetic method and application of chiral compound

The invention relates to a synthetic method of a chiral compound. The synthetic method comprises the following steps: taking 0.2720g of zinc chloride as a catalyst under water-free and oxygen-free conditions, weighing 2.0449g of acetylurea and 8.1397g of

Copper(II)-catalysed oxidative carbonylation of aminols and amines in water: A direct access to oxazolidinones, ureas and carbamates

Copper(II) chloride catalyses the oxidative carbonylation of aminols, amine and alcohols to give 2-oxazolidinones, ureas and carbamates. Reaction proceeds smoothly in water under homogeneous conditions (Ptot = 4 MPa; PO2 = 0.6 MPa, PCO), at 100°C in relatively short reaction times (4 h) and without using bases or any other additives. This methodology represents an economic and environmentally benign non-phosgene alternative for the preparation of these three important N-containing carbonyl compounds.