Technology Process of 4-(2-nitrophenyl)-4-oxobutanoic acid
There total 6 articles about 4-(2-nitrophenyl)-4-oxobutanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-(2-nitrophenyl)butane-1,4-diol;
With
Dess-Martin periodane;
In
dichloromethane;
at 20 ℃;
for 2h;
Inert atmosphere;
With
chromium(VI) oxide; sulfuric acid;
In
water; acetone;
at 0 ℃;
for 0.75h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: titanium tetrachloride / tetrahydrofuran; dichloromethane / 0.33 h / 0 °C / Inert atmosphere
1.2: 0.25 h / 0 °C / Inert atmosphere
2.1: diborane; cyclohexene / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere
2.2: 0.5 h / 20 °C / Inert atmosphere
3.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C / Inert atmosphere
3.2: 0.75 h / 0 °C / Inert atmosphere
With
titanium tetrachloride; Dess-Martin periodane; diborane; cyclohexene;
In
tetrahydrofuran; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: diborane; cyclohexene / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C / Inert atmosphere
2.2: 0.75 h / 0 °C / Inert atmosphere
With
Dess-Martin periodane; diborane; cyclohexene;
In
tetrahydrofuran; dichloromethane;
