(2S,3R)-4-tert-butyldiphenylsilyloxy-1,2-epoxy-3-methylbutane

Base Information

• Chemical Name: (2S,3R)-4-tert-butyldiphenylsilyloxy-1,2-epoxy-3-methylbutane
• CAS No.: 154955-34-7
• Molecular Formula: C₂₁H₂₈O₂Si
• Molecular Weight: 340.538
• Mol file: 154955-34-7.mol

Synonyms:(2S,3R)-4-tert-butyldiphenylsilyloxy-1,2-epoxy-3-methylbutane

Chemical Property of (2S,3R)-4-tert-butyldiphenylsilyloxy-1,2-epoxy-3-methylbutane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3R)-4-tert-butyldiphenylsilyloxy-1,2-epoxy-3-methylbutane

There total 10 articles about (2S,3R)-4-tert-butyldiphenylsilyloxy-1,2-epoxy-3-methylbutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(2R,3R)-4-((tert-butyldiphenylsilyl)oxy)-2-chloro-3-methylbutan-1-ol (1487462-76-9) → (2S,3R)-4-tert-butyldiphenylsilyloxy-1,2-epoxy-3-methylbutane (154955-34-7)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 60 ℃; for 4h; Inert atmosphere;

DOI:10.1021/jo401996m

Reference yield:

(2S,3R)-4-tert-butyldiphenylsilyloxy-2-hydroxy-3-methylbutyl p-toluenesulfonate (154955-33-6) → (2S,3R)-4-tert-butyldiphenylsilyloxy-1,2-epoxy-3-methylbutane (154955-34-7)

Guidance literature:

With potassium carbonate; In methanol; for 2h; Yield given; Ambient temperature;

Reference yield:

(2S,3R)-4-(tert-butyldiphenylsilyloxy)-3-methylbutane-1,2-diol (151698-78-1) → (2S,3R)-4-tert-butyldiphenylsilyloxy-1,2-epoxy-3-methylbutane (154955-34-7)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 12 h / 4 °C

2: K₂CO₃ / methanol / 2 h / Ambient temperature

With pyridine; potassium carbonate; In methanol;

upstream raw materials:

(2S,3R)-4-tert-butyldiphenylsilyloxy-2-hydroxy-3-methylbutyl p-toluenesulfonate

(2S,3R)-4-(tert-butyldiphenylsilyloxy)-3-methylbutane-1,2-diol

(E)-4-methoxy-3-methyl-4-oxobut-2-enoic acid

(E)-4-hydroxy-3-methylbut-2-enoic acid

Downstream raw materials:

(2R,3R)-1-tert-butyldiphenylsilyloxy-2-methyl-3-heptanol

(2R,3R,6S)-1-(tert-butyldiphenylsilyloxy)-2,6-dimethyl-3-octanol

(2R,3R,2'RS)-1-(tert-butyldiphenylsilyloxy)-2-methyl-3-(tetrahydro-2'H-pyran-2'-yloxy)heptane