2-Butenoic acid, 4-hydroxy-3-methyl-, (E)-

Base Information

• Chemical Name: 2-Butenoic acid, 4-hydroxy-3-methyl-, (E)-
• CAS No.: 44647-19-0
• Molecular Formula: C5H8O3
• Molecular Weight: 116.117
• Mol file: 44647-19-0.mol

Synonyms:3-hydroxymethylisocrotonic acid;1-Hydroxy-2-methyl-buten-(2)-saeure-(4);4-Hydroxy-3-methyl-trans-crotonsaeure;(E)-4-Hydroxy-3-methyl-but-2-enoic acid;4-hydroxy-3-methyl-crotonic acid;4-hydroxy-3-methyl-trans-crotonic acid;3-(hydroxymethyl)isocrotonic acid;

Chemical Property of 2-Butenoic acid, 4-hydroxy-3-methyl-, (E)-

Chemical Property:

• PSA: 57.53000
• LogP: 0.00960

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Butenoic acid, 4-hydroxy-3-methyl-, (E)-

There total 2 articles about 2-Butenoic acid, 4-hydroxy-3-methyl-, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tetrachloromethane (56-23-5) + 2-bromo-3-methyl-crotonic acid (1578-14-9) → (E)-4-hydroxy-3-methylbut-2-enoic acid (44647-19-0) + 3-methyl-2-ketobutanoic acid (759-05-7) + 2-hydroxy-3-methylbut-3-enoic acid (91496-47-8)

Guidance literature:

at 100 ℃;

Reference yield:

α-chloro β-dimethyl acrylic acid (15052-93-4) → (E)-4-hydroxy-3-methylbut-2-enoic acid (44647-19-0) + 3-methyl-2-ketobutanoic acid (759-05-7)

Guidance literature:

DOI:10.1039/jr9580004113

Reference yield: 7.0%

(E)-4-hydroxy-3-methylbut-2-enoic acid (44647-19-0) → (S)-4-Hydroxy-3-methyl-butyric acid (77220-86-1,108772-87-8) + (R)-4-Hydroxy-3-methyl-butyric acid (108772-87-8)

Guidance literature:

With hydrogen; Ru<(R)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl>(OCOCH3)2; In methanol; at 15 - 30 ℃; for 16h; under 65360 Torr; Title compound not separated from byproducts;

DOI:10.1021/jo00390a043

upstream raw materials:

tetrachloromethane

2-bromo-3-methyl-crotonic acid

α-chloro β-dimethyl acrylic acid

Downstream raw materials:

4-hydroxy-3-methylbutanoic acid

(S)-4-Hydroxy-3-methyl-butyric acid

(R)-4-Hydroxy-3-methyl-butyric acid

hydroxy-2-propanone