N-(3-(3,4-dichlorophenyl)propyl)-4-(3-(3,4-dichlorophenyl)-propylamino)-1-ethyl-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide

Base Information

• Chemical Name: N-(3-(3,4-dichlorophenyl)propyl)-4-(3-(3,4-dichlorophenyl)-propylamino)-1-ethyl-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide
• CAS No.: 1429291-82-6
• Molecular Formula: C₂₅H₂₇Cl₄N₃O₂
• Molecular Weight: 543.32
• Mol file: 1429291-82-6.mol

Synonyms:N-(3-(3,4-dichlorophenyl)propyl)-4-(3-(3,4-dichlorophenyl)-propylamino)-1-ethyl-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide

Chemical Property of N-(3-(3,4-dichlorophenyl)propyl)-4-(3-(3,4-dichlorophenyl)-propylamino)-1-ethyl-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-(3,4-dichlorophenyl)propyl)-4-(3-(3,4-dichlorophenyl)-propylamino)-1-ethyl-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide

There total 4 articles about N-(3-(3,4-dichlorophenyl)propyl)-4-(3-(3,4-dichlorophenyl)-propylamino)-1-ethyl-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.2%

1-ethyl-4,5-dioxopyrrolidine-3-carboxylic acid (1429293-24-2) + 3-(3,4-dichlorophenyl)propan-1-amine (76706-60-0) → N-(3-(3,4-dichlorophenyl)propyl)-4-(3-(3,4-dichlorophenyl)-propylamino)-1-ethyl-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide (1429291-82-6)

Guidance literature:

1-ethyl-4,5-dioxopyrrolidine-3-carboxylic acid; With oxalyl dichloride; In dichloromethane; at 20 ℃; for 2.5h;

3-(3,4-dichlorophenyl)propan-1-amine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

ethyl 1-ethyl-4,5-dioxopyrrolidine-3-carboxylate (5336-43-6) → N-(3-(3,4-dichlorophenyl)propyl)-4-(3-(3,4-dichlorophenyl)-propylamino)-1-ethyl-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide (1429291-82-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hydroxide; water / tetrahydrofuran / 1 h / 80 °C / Microwave irradiation

2.1: oxalyl dichloride / dichloromethane / 2.5 h / 20 °C

2.2: 16 h / 20 °C

With oxalyl dichloride; water; lithium hydroxide; In tetrahydrofuran; dichloromethane;

Reference yield:

3(3,4-dichlorophenyl)propanoic acid (25173-68-6) → N-(3-(3,4-dichlorophenyl)propyl)-4-(3-(3,4-dichlorophenyl)-propylamino)-1-ethyl-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide (1429291-82-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2.83 h / 0 - 20 °C

1.2: 16 h / 0 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 60 °C / Inert atmosphere

3.1: oxalyl dichloride / dichloromethane / 2.5 h / 20 °C

3.2: 16 h / 20 °C

With lithium aluminium tetrahydride; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

upstream raw materials:

3-(3,4-dichlorophenyl)propionamide

1-ethyl-4,5-dioxopyrrolidine-3-carboxylic acid

3-(3,4-dichlorophenyl)propan-1-amine

ethyl 1-ethyl-4,5-dioxopyrrolidine-3-carboxylate