3-(3,5-dimethoxyphenyl)-7-(tritylamino)-1,6-naphthyridin-2-ylformamide

Base Information

• Chemical Name: 3-(3,5-dimethoxyphenyl)-7-(tritylamino)-1,6-naphthyridin-2-ylformamide
• CAS No.: 311819-99-5
• Molecular Formula: C₃₆H₃₀N₄O₃
• Molecular Weight: 566.659
• Mol file: 311819-99-5.mol

Synonyms:3-(3,5-dimethoxyphenyl)-7-(tritylamino)-1,6-naphthyridin-2-ylformamide

Chemical Property of 3-(3,5-dimethoxyphenyl)-7-(tritylamino)-1,6-naphthyridin-2-ylformamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3,5-dimethoxyphenyl)-7-(tritylamino)-1,6-naphthyridin-2-ylformamide

There total 1 articles about 3-(3,5-dimethoxyphenyl)-7-(tritylamino)-1,6-naphthyridin-2-ylformamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

trityl chloride (76-83-5) + N,N-dimethyl-formamide (68-12-2,33513-42-7) + 3-(3,5-Dimethoxyphenyl)-1,6-naphthyridine-2,7-diamine (293301-09-4) → 3-(3,5-dimethoxyphenyl)-N7-trityl-1,6-naphthyridine-2,7-diamine (311820-00-5) + 3-(3,5-dimethoxyphenyl)-7-(tritylamino)-1,6-naphthyridin-2-ylformamide (311819-99-5)

Guidance literature:

3-(3,5-Dimethoxyphenyl)-1,6-naphthyridine-2,7-diamine; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.416667h;

trityl chloride; N,N-dimethyl-formamide; at 20 ℃; for 24h; Further stages.;

DOI:10.1021/jm000161d

Reference yield: 79.0%

3-(3,5-dimethoxyphenyl)-7-(tritylamino)-1,6-naphthyridin-2-ylformamide (311819-99-5) → 3-(3,5-dimethoxyphenyl)-N7-trityl-1,6-naphthyridine-2,7-diamine (311820-00-5)

Guidance literature:

With sodium hydroxide; In methanol; dichloromethane; at 40 ℃; for 2.5h;

DOI:10.1021/jm000161d

Reference yield:

3-(3,5-dimethoxyphenyl)-7-(tritylamino)-1,6-naphthyridin-2-ylformamide (311819-99-5) → 3-(3,5-dimethoxyphenyl)-N2-(4-methoxybenzyl)-1,6-naphthyridine-2,7-diamine

Guidance literature:

Multi-step reaction with 5 steps

1.1: 79 percent / aq. NaOH / methanol; CH₂Cl₂ / 2.5 h / 40 °C

2.1: NaH / dimethylformamide / 0.03 h / 20 °C

2.2: dimethylformamide / 2 h / 20 °C

3.1: silica gel / CH₂Cl₂ / 48 h / 20 °C

4.1: NaH / dimethylformamide / 0.08 h / 20 °C

4.2: 62 percent / dimethylformamide / 24 h / 20 °C

5.1: 23 percent / TFA / 0.08 h / 50 °C

With sodium hydroxide; silica gel; sodium hydride; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm000161d

upstream raw materials:

trityl chloride

N,N-dimethyl-formamide

3-(3,5-Dimethoxyphenyl)-1,6-naphthyridine-2,7-diamine

Downstream raw materials:

3-(3,5-dimethoxyphenyl)-N⁷-trityl-1,6-naphthyridine-2,7-diamine

3-(3,5-Dimethoxyphenyl)-1,6-naphthyridine-2,7-diamine

1-[7-amino-3-(3,5-dimethoxy-phenyl)-[1,6]naphthyridin-2-yl]-3-tert-butyl-urea

N-[2-[[(tert-butylamino)carbonyl]amino]-3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-7-yl]acetamide