(1R,2S)-1-phenyl-2-{(S)-2-(p-toluenesulfinyl)phenyl}-2-triisopropylsilanyloxyethylamine

Base Information

Chemical Name:(1R,2S)-1-phenyl-2-{(S)-2-(p-toluenesulfinyl)phenyl}-2-triisopropylsilanyloxyethylamine
CAS No.:620141-00-6
Molecular Formula:C₃₀H₄₁NO₂SSi
Molecular Weight:507.813
Hs Code.:

Synonyms:(1R,2S)-1-phenyl-2-{(S)-2-(p-toluenesulfinyl)phenyl}-2-triisopropylsilanyloxyethylamine

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Chemical Property of (1R,2S)-1-phenyl-2-{(S)-2-(p-toluenesulfinyl)phenyl}-2-triisopropylsilanyloxyethylamine

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Technology Process of (1R,2S)-1-phenyl-2-{(S)-2-(p-toluenesulfinyl)phenyl}-2-triisopropylsilanyloxyethylamine

There total 3 articles about (1R,2S)-1-phenyl-2-{(S)-2-(p-toluenesulfinyl)phenyl}-2-triisopropylsilanyloxyethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 620140-01-4
[1R,2S,(S)S]-N-{1-phenyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]-2-triisopropylsilanyloxyethyl}-p-toluenesulfinamide

: 620141-00-6
(1R,2S)-1-phenyl-2-{(S)-2-(p-toluenesulfinyl)phenyl}-2-triisopropylsilanyloxyethylamine

Guidance literature:: With trifluoroacetic acid; In methanol; at 0 ℃; for 3h;
DOI:10.1021/ol0358410

Reference yield:

: 350479-90-2
(S,E)-N-benzylidene-4-methylbenzenesulfinamide

: 620141-00-6
(1R,2S)-1-phenyl-2-{(S)-2-(p-toluenesulfinyl)phenyl}-2-triisopropylsilanyloxyethylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: 81 percent / tetrahydrofuran; hexane / -78 °C

2.1: 91 percent / TFA / methanol / 3 h / 0 °C

With trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane;
DOI:10.1021/ol0358410

Reference yield:

: 302934-11-8
(S)-2-(Triisopropylsyloxymethyl)phenyl p-tolylsulfoxide

: 620141-00-6
(1R,2S)-1-phenyl-2-{(S)-2-(p-toluenesulfinyl)phenyl}-2-triisopropylsilanyloxyethylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: 81 percent / tetrahydrofuran; hexane / -78 °C

2.1: 91 percent / TFA / methanol / 3 h / 0 °C

With trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane;
DOI:10.1021/ol0358410