[1R,2S,(S)S]-N-{1-phenyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]-2-triisopropylsilanyloxyethyl}-p-toluenesulfinamide

Base Information

• Chemical Name: [1R,2S,(S)S]-N-{1-phenyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]-2-triisopropylsilanyloxyethyl}-p-toluenesulfinamide
• CAS No.: 620140-01-4
• Molecular Formula: C₃₇H₄₇NO₃S₂Si
• Molecular Weight: 646.003

Synonyms:[1R,2S,(S)S]-N-{1-phenyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]-2-triisopropylsilanyloxyethyl}-p-toluenesulfinamide

Chemical Property of [1R,2S,(S)S]-N-{1-phenyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]-2-triisopropylsilanyloxyethyl}-p-toluenesulfinamide

Chemical Property:

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MSDS Files:

SDS file from LookChem

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Technology Process of [1R,2S,(S)S]-N-{1-phenyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]-2-triisopropylsilanyloxyethyl}-p-toluenesulfinamide

There total 1 articles about [1R,2S,(S)S]-N-{1-phenyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]-2-triisopropylsilanyloxyethyl}-p-toluenesulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(S,E)-N-benzylidene-4-methylbenzenesulfinamide (350479-90-2) + (S)-2-(Triisopropylsyloxymethyl)phenyl p-tolylsulfoxide (302934-11-8) → [1R,2S,(S)S]-N-{1-phenyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]-2-triisopropylsilanyloxyethyl}-p-toluenesulfinamide (620140-01-4)

Guidance literature:

(S)-2-(Triisopropylsyloxymethyl)phenyl p-tolylsulfoxide; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

(S,E)-N-benzylidene-4-methylbenzenesulfinamide; In tetrahydrofuran; hexane; at -78 ℃;

DOI:10.1021/ol0358410

Reference yield: 95.0%

[1R,2S,(S)S]-N-{1-phenyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]-2-triisopropylsilanyloxyethyl}-p-toluenesulfinamide (620140-01-4) → [1R,2S,(S)S]-N-{2-hydroxy-1-phenyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]ethyl}-p-toluenesulfinamide (620140-92-3)

Guidance literature:

With tetrabutyl ammonium fluoride; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1021/ol0358410

Reference yield: 91.0%

[1R,2S,(S)S]-N-{1-phenyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]-2-triisopropylsilanyloxyethyl}-p-toluenesulfinamide (620140-01-4) → (1R,2S)-1-phenyl-2-{(S)-2-(p-toluenesulfinyl)phenyl}-2-triisopropylsilanyloxyethylamine (620141-00-6)

Guidance literature:

With trifluoroacetic acid; In methanol; at 0 ℃; for 3h;

DOI:10.1021/ol0358410

upstream raw materials:

(S,E)-N-benzylidene-4-methylbenzenesulfinamide

(S)-2-(Triisopropylsyloxymethyl)phenyl p-tolylsulfoxide

Downstream raw materials:

(1R,2S)-1,2-diphenyl-2-triisopropylsilanyloxyethylamine

(1R,2S)-1-phenyl-2-{(S)-2-(p-toluenesulfinyl)phenyl}-2-triisopropylsilanyloxyethylamine

[1R,2S,(S)S]-N-{2-hydroxy-1-phenyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]ethyl}-p-toluenesulfinamide

(1S,2R)-2-Amino-1,2-diphenylethanol

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