(3-allyloxy-5,6-difluoro-2-nitrophenyl)-(4-iodophenyl)-amine

Base Information

• Chemical Name: (3-allyloxy-5,6-difluoro-2-nitrophenyl)-(4-iodophenyl)-amine
• CAS No.: 1287794-81-3
• Molecular Formula: C₁₅H₁₁F₂IN₂O₃
• Molecular Weight: 432.165
• Mol file: 1287794-81-3.mol

Synonyms:(3-allyloxy-5,6-difluoro-2-nitrophenyl)-(4-iodophenyl)-amine

Chemical Property of (3-allyloxy-5,6-difluoro-2-nitrophenyl)-(4-iodophenyl)-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-allyloxy-5,6-difluoro-2-nitrophenyl)-(4-iodophenyl)-amine

There total 3 articles about (3-allyloxy-5,6-difluoro-2-nitrophenyl)-(4-iodophenyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzene, 1,2,3-trifluoro-4-nitro-5-(2-propen-1-yloxy) (1287794-78-8) + p-aminoiodobenzene (540-37-4) → (3-allyloxy-5,6-difluoro-2-nitrophenyl)-(4-iodophenyl)-amine (1287794-81-3)

Guidance literature:

p-aminoiodobenzene; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

benzene, 1,2,3-trifluoro-4-nitro-5-(2-propen-1-yloxy); In tetrahydrofuran; at -78 - 20 ℃; for 17h;

Reference yield:

3,4,5-trifluorophenol (99627-05-1) → (3-allyloxy-5,6-difluoro-2-nitrophenyl)-(4-iodophenyl)-amine (1287794-81-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: nitric acid; acetic acid / 0.75 h / 4 - 20 °C

2.1: potassium carbonate / acetone / 2 h / Reflux

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

3.2: 17 h / -78 - 20 °C

With nitric acid; potassium carbonate; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; acetone;

Reference yield:

phenol, 3,4,5-trifluoro-2-nitro (923033-24-3) → (3-allyloxy-5,6-difluoro-2-nitrophenyl)-(4-iodophenyl)-amine (1287794-81-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / acetone / 2 h / Reflux

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

2.2: 17 h / -78 - 20 °C

With potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; acetone;

upstream raw materials:

benzene, 1,2,3-trifluoro-4-nitro-5-(2-propen-1-yloxy)

p-aminoiodobenzene

3,4,5-trifluorophenol

phenol, 3,4,5-trifluoro-2-nitro

Downstream raw materials:

C₁₉H₁₉F₂IN₂O₅S

C₁₉H₁₇F₂IN₂O₃S

C₂₁H₂₁F₂IN₂O₃S

6-allyloxy-3,4-difluoro-N₂-(4-iodophenyl)-benzene-1,2-diamine