[2-(4-Bromo-2-fluoro-benzyl)-4-chloro-6-fluoro-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-4-yl]-acetyl chloride

Base Information

Chemical Name:[2-(4-Bromo-2-fluoro-benzyl)-4-chloro-6-fluoro-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-4-yl]-acetyl chloride
CAS No.:1027282-15-0
Molecular Formula:C₁₈H₁₀BrCl₂F₂NO₃
Molecular Weight:477.089
Hs Code.:

Synonyms:[2-(4-Bromo-2-fluoro-benzyl)-4-chloro-6-fluoro-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-4-yl]-acetyl chloride

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Chemical Property of [2-(4-Bromo-2-fluoro-benzyl)-4-chloro-6-fluoro-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-4-yl]-acetyl chloride

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Technology Process of [2-(4-Bromo-2-fluoro-benzyl)-4-chloro-6-fluoro-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-4-yl]-acetyl chloride

There total 1 articles about [2-(4-Bromo-2-fluoro-benzyl)-4-chloro-6-fluoro-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-4-yl]-acetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 133891-93-7
2-[(4-bromo-2-fluorophenyl)methyl]-6-fluoro-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolineacetic acid

: 1027282-15-0
[2-(4-Bromo-2-fluoro-benzyl)-4-chloro-6-fluoro-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-4-yl]-acetyl chloride

Guidance literature:: With thionyl chloride; In toluene; at 85 ℃; for 4h;
DOI:10.1002/jhet.5570310254 DOI:10.1021/jm00039a018

Reference yield:

: 1027282-15-0
[2-(4-Bromo-2-fluoro-benzyl)-4-chloro-6-fluoro-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-4-yl]-acetyl chloride

: 2-[(4-Bromo-2-fluorophenyl)methyl]-4-chloro-6-fluoro-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolineacetamide

Guidance literature:: With ammonia; In tetrahydrofuran; at 0 ℃; for 0.333333h;
DOI:10.1002/jhet.5570310254

Reference yield:

: 1027282-15-0
[2-(4-Bromo-2-fluoro-benzyl)-4-chloro-6-fluoro-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-4-yl]-acetyl chloride

: 2'-[(4-Bromo-2-fluorophenyl)methyl]-6'-fluorospiro[azetidine-2,4'(1'H)-isoquinoline]-1',3',4(2'H)-trione

Guidance literature:: Multi-step reaction with 2 steps

1: NH₃ / tetrahydrofuran / 0.33 h / 0 °C

2: NaH / dimethylformamide / 0.5 h

With ammonia; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00039a018