2-[(4-bromo-2-fluorophenyl)methyl]-6-fluoro-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolineacetic acid

Base Information

Chemical Name:2-[(4-bromo-2-fluorophenyl)methyl]-6-fluoro-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolineacetic acid
CAS No.:133891-93-7
Molecular Formula:C₁₈H₁₂BrF₂NO₄
Molecular Weight:424.198
Hs Code.:

Synonyms:2-[(4-bromo-2-fluorophenyl)methyl]-6-fluoro-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolineacetic acid

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Chemical Property of 2-[(4-bromo-2-fluorophenyl)methyl]-6-fluoro-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolineacetic acid

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Technology Process of 2-[(4-bromo-2-fluorophenyl)methyl]-6-fluoro-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolineacetic acid

There total 11 articles about 2-[(4-bromo-2-fluorophenyl)methyl]-6-fluoro-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolineacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 129688-85-3
2-<(4-bromo-2-fluorophenyl)methyl>-6-fluoro-1,2,3,4-tetrahydro-4-(methoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid

: 133891-93-7
2-[(4-bromo-2-fluorophenyl)methyl]-6-fluoro-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolineacetic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; water; for 0.5h;
DOI:10.1021/jm00039a018

Reference yield:

: 1026328-27-7
[2-(4-Bromo-2-fluoro-benzyl)-6-fluoro-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-4-yl]-acetic acid tert-butyl ester

: 133891-93-7
2-[(4-bromo-2-fluorophenyl)methyl]-6-fluoro-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolineacetic acid

Guidance literature:: With sodium hydroxide; In dichloromethane; for 5h; Ambient temperature;
DOI:10.1002/jhet.5570310254

Reference yield:

: 1006-41-3
2-bromo-4-fluorobenzoic acid

: 133891-93-7
2-[(4-bromo-2-fluorophenyl)methyl]-6-fluoro-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolineacetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: NaH, CuBr / 1.) RT, 10 min, 2.) 70 deg C, 30 min

2: SOCl₂ / 1.5 h / Heating

3: TEA / tetrahydrofuran / 0.5 h

4: K₂CO₃ / dimethylformamide / 1 h / 85 °C

5: 2N aq. NaOH / CH₂Cl₂ / 5 h / Ambient temperature

With sodium hydroxide; thionyl chloride; TEA; sodium hydride; potassium carbonate; copper(I) bromide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570310254