1-<(S)-1-(tert-butoxycarbonyl)ethyl>-(3R,4S)-3-<(3'S,4'R)-3-azido-4-phenylazetidin-2-on-1-yl>-4-phenylazetidin-2-one

Base Information

Chemical Name:1-<(S)-1-(tert-butoxycarbonyl)ethyl>-(3R,4S)-3-<(3'S,4'R)-3-azido-4-phenylazetidin-2-on-1-yl>-4-phenylazetidin-2-one
CAS No.:78738-81-5
Molecular Formula:C₂₅H₂₇N₅O₄
Molecular Weight:461.52
Hs Code.:

Synonyms:1-<(S)-1-(tert-butoxycarbonyl)ethyl>-(3R,4S)-3-<(3'S,4'R)-3-azido-4-phenylazetidin-2-on-1-yl>-4-phenylazetidin-2-one

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Chemical Property of 1-<(S)-1-(tert-butoxycarbonyl)ethyl>-(3R,4S)-3-<(3'S,4'R)-3-azido-4-phenylazetidin-2-on-1-yl>-4-phenylazetidin-2-one

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Technology Process of 1-<(S)-1-(tert-butoxycarbonyl)ethyl>-(3R,4S)-3-<(3'S,4'R)-3-azido-4-phenylazetidin-2-on-1-yl>-4-phenylazetidin-2-one

There total 7 articles about 1-<(S)-1-(tert-butoxycarbonyl)ethyl>-(3R,4S)-3-<(3'S,4'R)-3-azido-4-phenylazetidin-2-on-1-yl>-4-phenylazetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 30426-58-5
2-azidoacetyl chloride

: 78738-82-6
1-<(S)-1-(tert-butoxycarbonyl)ethyl>-(3R,4S)-3-(benzylideneamino)-4-phenylazetidin-2-one

: 78738-81-5
1-<(S)-1-(tert-butoxycarbonyl)ethyl>-(3R,4S)-3-<(3'S,4'R)-3-azido-4-phenylazetidin-2-on-1-yl>-4-phenylazetidin-2-one

Guidance literature:: With triethylamine; In dichloromethane; for 14h; -78 deg C to room temperature;
DOI:10.1021/ja00240a033

Reference yield: 48.0%

: 30426-58-5
2-azidoacetyl chloride

: 78688-68-3,78738-82-6
(S)-2-((3R,4S)-2-Oxo-4-phenyl-3-{[1-phenyl-meth-(E)-ylidene]-amino}-azetidin-1-yl)-propionic acid tert-butyl ester

: 78738-81-5
1-<(S)-1-(tert-butoxycarbonyl)ethyl>-(3R,4S)-3-<(3'S,4'R)-3-azido-4-phenylazetidin-2-on-1-yl>-4-phenylazetidin-2-one

Guidance literature:: With triethylamine; In dichloromethane; -78 deg C to r.t.;
DOI:10.1039/c39810000344

Reference yield:

: 100-52-7
benzaldehyde

: 78738-81-5
1-<(S)-1-(tert-butoxycarbonyl)ethyl>-(3R,4S)-3-<(3'S,4'R)-3-azido-4-phenylazetidin-2-on-1-yl>-4-phenylazetidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

2: 41 percent / NEt₃ / CH₂Cl₂ / -78 deg C to r.t.

3: H₂ / 5percent Pd-C / methanol / 760 Torr / Ambient temperature

4: 96 percent / MgSO₄ / benzene

5: 48 percent / NEt₃ / CH₂Cl₂ / -78 deg C to r.t.

With hydrogen; magnesium sulfate; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; benzene;
DOI:10.1039/c39810000344