[(S)-Hydroxy-(3-trifluoromethyl-phenyl)-methyl]-phosphonic acid diallyl ester

Base Information

Chemical Name:[(S)-Hydroxy-(3-trifluoromethyl-phenyl)-methyl]-phosphonic acid diallyl ester
CAS No.:536739-10-3
Molecular Formula:C₁₄H₁₆F₃O₄P
Molecular Weight:336.248
Hs Code.:

Synonyms:[(S)-Hydroxy-(3-trifluoromethyl-phenyl)-methyl]-phosphonic acid diallyl ester

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Chemical Property of [(S)-Hydroxy-(3-trifluoromethyl-phenyl)-methyl]-phosphonic acid diallyl ester

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Technology Process of [(S)-Hydroxy-(3-trifluoromethyl-phenyl)-methyl]-phosphonic acid diallyl ester

There total 4 articles about [(S)-Hydroxy-(3-trifluoromethyl-phenyl)-methyl]-phosphonic acid diallyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 536739-01-2
(3-trifluoromethyl-benzyl)-phosphonic acid diallyl ester

: 536739-10-3
[(S)-Hydroxy-(3-trifluoromethyl-phenyl)-methyl]-phosphonic acid diallyl ester

Guidance literature:: With sodium hexamethyldisilazane; (+)-[(8,8-dichlorocamphoryl)sulfonyl]oxaziridine; In tetrahydrofuran; at -78 ℃; for 3h;
DOI:10.1016/S0957-4166(02)00786-3

Reference yield:

: 146780-08-7
O,O-Diethyl 3-Trifluoromethylphenylmethylphosphonate

: 536739-10-3
[(S)-Hydroxy-(3-trifluoromethyl-phenyl)-methyl]-phosphonic acid diallyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 3 h / 0 °C

2: (COCl)2; DMF / CH₂Cl₂ / 1 h / 20 °C

3: 3.29 g / pyridine; DMAP / CH₂Cl₂ / -20 - 20 °C

4: 42 percent / NaHMDS; (+)-8,8-(dichlorocamphor)sulfonyloxaziridine / tetrahydrofuran / 3 h / -78 °C

With pyridine; dmap; oxalyl dichloride; sodium hexamethyldisilazane; (+)-[(8,8-dichlorocamphoryl)sulfonyl]oxaziridine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0957-4166(02)00786-3

Reference yield:

: C₈H₆Cl₂F₃OP

: 536739-10-3
[(S)-Hydroxy-(3-trifluoromethyl-phenyl)-methyl]-phosphonic acid diallyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 3.29 g / pyridine; DMAP / CH₂Cl₂ / -20 - 20 °C

2: 42 percent / NaHMDS; (+)-8,8-(dichlorocamphor)sulfonyloxaziridine / tetrahydrofuran / 3 h / -78 °C

With pyridine; dmap; sodium hexamethyldisilazane; (+)-[(8,8-dichlorocamphoryl)sulfonyl]oxaziridine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0957-4166(02)00786-3