7-chloro-3-[(6,7-dimethoxy-quinazolin-4-ylamino)methyl]-1-phenyl-1H-quinolin-4-one

Base Information

Chemical Name:7-chloro-3-[(6,7-dimethoxy-quinazolin-4-ylamino)methyl]-1-phenyl-1H-quinolin-4-one
CAS No.:1418025-25-8
Molecular Formula:C₂₆H₂₁ClN₄O₃
Molecular Weight:472.931
Hs Code.:

Synonyms:7-chloro-3-[(6,7-dimethoxy-quinazolin-4-ylamino)methyl]-1-phenyl-1H-quinolin-4-one

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Chemical Property of 7-chloro-3-[(6,7-dimethoxy-quinazolin-4-ylamino)methyl]-1-phenyl-1H-quinolin-4-one

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Technology Process of 7-chloro-3-[(6,7-dimethoxy-quinazolin-4-ylamino)methyl]-1-phenyl-1H-quinolin-4-one

There total 7 articles about 7-chloro-3-[(6,7-dimethoxy-quinazolin-4-ylamino)methyl]-1-phenyl-1H-quinolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1418026-20-6
3-bromomethyl-7-chloro-1-phenyl-1H-quinolin-4-one

: 21575-13-3
4-amino-6,7-dimethoxyquinazoline

: 1418025-25-8
7-chloro-3-[(6,7-dimethoxy-quinazolin-4-ylamino)methyl]-1-phenyl-1H-quinolin-4-one

Guidance literature:: 4-amino-6,7-dimethoxyquinazoline; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.25h; under 760.051 Torr; Inert atmosphere;

3-bromomethyl-7-chloro-1-phenyl-1H-quinolin-4-one; In N,N-dimethyl-formamide; mineral oil; at 50 ℃; for 3h; under 760.051 Torr; Inert atmosphere;

Reference yield:

: 1402345-30-5
4-chloro-N-methoxy-N-methyl-2-phenylamino-benzamide

: 1418025-25-8
7-chloro-3-[(6,7-dimethoxy-quinazolin-4-ylamino)methyl]-1-phenyl-1H-quinolin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 2 h / 0 - 20 °C / 760.05 Torr / Inert atmosphere

2.1: oxalyl dichloride / tetrahydrofuran / 1.5 h / 0 - 20 °C / 760.05 Torr / Inert atmosphere

2.2: 2 h / 115 °C / 760.05 Torr / Inert atmosphere

3.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 1 h / 115 °C / 760.05 Torr / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / 760.05 Torr / Inert atmosphere

4.2: 3 h / 50 °C / 760.05 Torr / Inert atmosphere

With N-Bromosuccinimide; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); sodium hydride; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1402345-31-6
1-(4-chloro-2-phenylamino-phenyl)propan-1-one

: 1418025-25-8
7-chloro-3-[(6,7-dimethoxy-quinazolin-4-ylamino)methyl]-1-phenyl-1H-quinolin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / tetrahydrofuran / 1.5 h / 0 - 20 °C / 760.05 Torr / Inert atmosphere

1.2: 2 h / 115 °C / 760.05 Torr / Inert atmosphere

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 1 h / 115 °C / 760.05 Torr / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / 760.05 Torr / Inert atmosphere

3.2: 3 h / 50 °C / 760.05 Torr / Inert atmosphere

With N-Bromosuccinimide; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); sodium hydride; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide; mineral oil;