2-Bromo-4-chlorobenzoic acid

Base Information

• Chemical Name: 2-Bromo-4-chlorobenzoic acid
• CAS No.: 936-08-3
• Molecular Formula: C7H4BrClO2
• Molecular Weight: 235.465
• Hs Code.: 2916399090
• Mol file: 936-08-3.mol

Synonyms:2-BROMO-4-CHLOROBENZOIC ACID;2-BroM-4-chlorobenzoic acid;2-BroMo-4-chlorobenz

Chemical Property of 2-Bromo-4-chlorobenzoic acid

Chemical Property:

• Melting Point: 159 °C
• Boiling Point: 326.5 °C at 760 mmHg
• PKA: 2.62±0.10(Predicted)
• Flash Point: 151.3 °C
• PSA: 37.30000
• Density: 1.809 g/cm³
• LogP: 2.80070
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-4-chlorobenzoic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi; N; C
• Hazard Codes: Xi,N,C,Xn
• Statements: 36/37/38-50-34-22
• Safety Statements: 26-36/37/39-61-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-4-chlorobenzoic acid

There total 9 articles about 2-Bromo-4-chlorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.2%

2-bromo-4-chloro-N-phenylbenzamide → 2-bromo-4-chlorobenzoic acid (936-08-3)

Guidance literature:

With sulfuric acid; In acetic acid; for 3h; Heating;

DOI:10.1007/BF00817261

Reference yield: 61.0%

2-Amino-4-chlorobenzoic acid (89-77-0) → 2-bromo-4-chlorobenzoic acid (936-08-3)

Guidance literature:

2-Amino-4-chlorobenzoic acid; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.0833333h;

With copper(I) bromide; In water; at 0 - 90 ℃;

DOI:10.1016/j.tet.2005.09.143

Reference yield:

4-chlorobenzanilide (6833-15-4) → 2-bromo-4-chlorobenzoic acid (936-08-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 61.2 percent / n-BuLi, 2-bromobenzyl bromide / tetrahydrofuran / 1.) -78 deg C, 0.5 h; r.t., 1 h, 2.) -78 deg C, 1 h; r.t., 1 h

2: 85.2 percent / conc. H₂SO₄ / aq. acetic acid / 3 h / Heating

With n-butyllithium; sulfuric acid; 1-Bromo-2-bromomethyl-benzene; In tetrahydrofuran; acetic acid;

DOI:10.1007/BF00817261

upstream raw materials:

2-bromo-4-chloro-1-methyl-benzene

2-Amino-4-chlorobenzoic acid

4-chlorobenzanilide

para-chlorotoluene

Downstream raw materials:

2-bromo-4-chlorobenzoyl chloride

4-chloro-2-(4-fluorophenylthio)-benzoic acid

N-phenyl-4-chloroanthranilic acid

4-bromo-2-chlorobenzoic acid methyl ester