4-[(4-chlorophenyl)methyl]-2-(1-methyl-hexahydro-1H-azepin-3-yl)-1(2H)-phthalazinone

Base Information

Chemical Name:4-[(4-chlorophenyl)methyl]-2-(1-methyl-hexahydro-1H-azepin-3-yl)-1(2H)-phthalazinone
CAS No.:905808-48-2
Molecular Formula:C₂₂H₂₄ClN₃O
Molecular Weight:381.905
Hs Code.:

Synonyms:4-[(4-chlorophenyl)methyl]-2-(1-methyl-hexahydro-1H-azepin-3-yl)-1(2H)-phthalazinone

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Chemical Property of 4-[(4-chlorophenyl)methyl]-2-(1-methyl-hexahydro-1H-azepin-3-yl)-1(2H)-phthalazinone

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Technology Process of 4-[(4-chlorophenyl)methyl]-2-(1-methyl-hexahydro-1H-azepin-3-yl)-1(2H)-phthalazinone

There total 5 articles about 4-[(4-chlorophenyl)methyl]-2-(1-methyl-hexahydro-1H-azepin-3-yl)-1(2H)-phthalazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1279126-12-3
4-[(4-chlorophenyl)methyl]-2-(hexahydro-1H-azepin-3-yl)-1(2H)-phthalazinone

: 905808-48-2
4-[(4-chlorophenyl)methyl]-2-(1-methyl-hexahydro-1H-azepin-3-yl)-1(2H)-phthalazinone

Guidance literature:: With formic acid; In water; at 80 ℃;
DOI:10.1021/jm1013874

Reference yield:

: 1279126-10-1
1,1-dimethylethyl 3-[4-[(4-chlorophenyl)methyl]-1-oxo-2(1H)-phthalazinyl]-hexahydro-1H-azepine-1-carboxylate

: 905808-48-2
4-[(4-chlorophenyl)methyl]-2-(1-methyl-hexahydro-1H-azepin-3-yl)-1(2H)-phthalazinone

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane

2: formic acid / water / 80 °C

With formic acid; trifluoroacetic acid; In dichloromethane; water; 2: Eschweiler-Clarke reaction;
DOI:10.1021/jm1013874

Reference yield:

: 1279126-03-2
1-(2-propen-1-ylamino)-4-penten-2-ol

: 905808-48-2
4-[(4-chlorophenyl)methyl]-2-(1-methyl-hexahydro-1H-azepin-3-yl)-1(2H)-phthalazinone

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane

2.1: Grubbs catalyst first generation / dichloromethane / Reflux; Inert atmosphere

2.2: 20 °C / 760.05 Torr

3.1: di-tert-butyl-diazodicarboxylate; triphenylphosphine / tetrahydrofuran / -15 - 20 °C

4.1: trifluoroacetic acid / dichloromethane

5.1: formic acid / water / 80 °C

With Grubbs catalyst first generation; formic acid; di-tert-butyl-diazodicarboxylate; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; 3.1: Mitsunobu reaction / 5.1: Eschweiler-Clarke reaction;
DOI:10.1021/jm1013874