benzyl (2-O-(R)-10-methyloctadecanoyl-1-O-hexadecanoyl-sn-glycero)-diisopropylphosphoramidite

Base Information

Chemical Name:benzyl (2-O-(R)-10-methyloctadecanoyl-1-O-hexadecanoyl-sn-glycero)-diisopropylphosphoramidite
CAS No.:935852-35-0
Molecular Formula:C₅₁H₉₄NO₆P
Molecular Weight:848.284
Hs Code.:

Synonyms:benzyl (2-O-(R)-10-methyloctadecanoyl-1-O-hexadecanoyl-sn-glycero)-diisopropylphosphoramidite

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl (2-O-(R)-10-methyloctadecanoyl-1-O-hexadecanoyl-sn-glycero)-diisopropylphosphoramidite

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Technology Process of benzyl (2-O-(R)-10-methyloctadecanoyl-1-O-hexadecanoyl-sn-glycero)-diisopropylphosphoramidite

There total 9 articles about benzyl (2-O-(R)-10-methyloctadecanoyl-1-O-hexadecanoyl-sn-glycero)-diisopropylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 935852-34-9
2-O-((R)-10-methyloctadecanoyl)-1-O-palmitoyl-sn-glycerol

: 108549-21-9
benzyl-N,N,N',N'-tetraisopropylphosphorodiamidite

: 935852-35-0
benzyl (2-O-(R)-10-methyloctadecanoyl-1-O-hexadecanoyl-sn-glycero)-diisopropylphosphoramidite

Guidance literature:: With 1H-tetrazole; In dichloromethane; at 20 ℃; for 1.5h;
DOI:10.1021/jo0625599

Reference yield:

: 927868-89-1
(R)-4-methyldodecanal

: 935852-35-0
benzyl (2-O-(R)-10-methyloctadecanoyl-1-O-hexadecanoyl-sn-glycero)-diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 7 steps

1.1: 75 percent / tetrahydrofuran / 16 h / 20 °C

2.1: 93 percent / pyridine / CH₂Cl₂ / 72 h / 0 °C

3.1: Al₂O₃ / diethyl ether / 17 h / 20 °C

3.2: 1.84 g / H₂ / Pd/C / hexane / 72 h

4.1: 98 percent / KMnO₄; n-Bu₄NBr; AcOH / H₂O; CH₂Cl₂ / 4 h / Heating

5.1: 89 percent / DCC; DMAP / CH₂Cl₂ / 20 °C

6.1: 93 percent / H₂; AcOH / Pd/C / ethanol / 1.5 h / 20 °C

7.1: 92 percent / 1H-tetrazole / CH₂Cl₂ / 1.5 h / 20 °C

With pyridine; 1H-tetrazole; dmap; aluminum oxide; potassium permanganate; tetrabutylammomium bromide; hydrogen; acetic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water;
DOI:10.1021/jo0625599

Reference yield:

: 883878-56-6
(R)-10-methyloctadecan-1-ol

: 935852-35-0
benzyl (2-O-(R)-10-methyloctadecanoyl-1-O-hexadecanoyl-sn-glycero)-diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / KMnO₄; n-Bu₄NBr; AcOH / H₂O; CH₂Cl₂ / 4 h / Heating

2: 89 percent / DCC; DMAP / CH₂Cl₂ / 20 °C

3: 93 percent / H₂; AcOH / Pd/C / ethanol / 1.5 h / 20 °C

4: 92 percent / 1H-tetrazole / CH₂Cl₂ / 1.5 h / 20 °C

With 1H-tetrazole; dmap; potassium permanganate; tetrabutylammomium bromide; hydrogen; acetic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; dichloromethane; water;
DOI:10.1021/jo0625599